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A systematic review of seizure clusters: Prevalence, risk factors, burden of disease and treatment patterns.

Author: ChoiEun Jung, ChungSteve, HirschLawrence J, KaurGavneet, KharawalaSaifuddin, SzaflarskiJerzy P, WilsonJessica Claire

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review analyzes the burden of seizure clusters (SCs) in patients with epilepsy, and the treatment patterns of rescue medications (RMs). SCs are associated with higher seizure frequency, treatment resistance, and lower remission rates. While RMs are under-prescribed, there's an urgent need to improve recognition and utilization of RMs for managing SCs.
Paper Details　
Original Abstract of the Article :
Seizure clusters (SCs) are episodes of consecutive seizures that occur within a short period. The treatment patterns of rescue medications (RMs), as well as the burden of SCs, have not been assessed. A systematic literature search on Embase.com (in PubMed and Embase), supplemented with keyword-based...See full text at original site
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引用元：
https://doi.org/10.1016/j.eplepsyres.2021.106748

データ提供：米国国立医学図書館（NLM）

Seizure Clusters: A Challenging Aspect of Epilepsy

Epilepsy is a chronic neurological disorder characterized by recurrent seizures. Seizure clusters, which are episodes of multiple seizures occurring within a short time frame, can be particularly challenging for patients and their families. This study, published in Epilepsy & Behavior, provides a comprehensive review of the prevalence, risk factors, impact, and treatment patterns of seizure clusters.

Understanding the Burden of Seizure Clusters

The review found that seizure clusters are a common occurrence, affecting a significant percentage of individuals with epilepsy. They are associated with several adverse factors, including an increased risk of status epilepticus, treatment resistance, and a lower likelihood of seizure remission. Seizure clusters also have a negative impact on quality of life, leading to increased hospitalizations, decreased productivity, and a greater burden on caregivers.

Optimizing Treatment for Seizure Clusters

The study highlights the need for improved recognition and management of seizure clusters. Despite their significant impact, rescue medications are often underutilized due to factors such as the lack of seizure action plans, poor communication between patients and healthcare providers, and concerns regarding administration routes. This research emphasizes the need for better strategies to address these challenges and optimize treatment for individuals experiencing seizure clusters.

Dr.Camel's Conclusion

Epilepsy, like the vastness of the desert, can be unpredictable and challenging. This study brings to light the significant impact of seizure clusters, which can be like a series of sudden sandstorms. It emphasizes the importance of collaboration between patients, families, and healthcare providers to develop comprehensive and effective treatment plans to navigate the challenges of epilepsy.

Date :
  1. Date Completed 2022-03-29
  2. Date Revised 2022-04-01
Further Info :

Pubmed ID

34521043

DOI: Digital Object Identifier

10.1016/j.eplepsyres.2021.106748

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・Effective treatment of seizures
SNS
PICO Info
in preparation
Languages

English

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