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Oestrogen therapy for postpartum depression: efficacy and adverse effects. A double-blind, randomized, placebo-controlled pilot study.

Author: HintikkaJukka, KettunenPirjo, KoistinenEeva, PerheentupaAntti

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oestradiol treatment was not found to be more effective than placebo in treating postpartum depression (PPD) in a pilot study. Further research is needed to evaluate oestrogen therapy for PPD, with and without antidepressant and gestagen therapy.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Postpartum depression (PPD) is detrimental to the mother and the family as a whole. Early initiation of appropriate treatment is important. The aim of this pilot study was to evaluate the efficacy and adverse effects of oestradiol treatment. METHODS: We performed a pilot double-blind, r...See full text at original site
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引用元：
https://doi.org/10.1080/08039488.2021.1974556

データ提供：米国国立医学図書館（NLM）

Oestrogen Therapy for Postpartum Depression: Efficacy and Adverse Effects. A Double-Blind, Randomized, Placebo-Controlled Pilot Study

Postpartum depression (PPD), a common and potentially debilitating condition, can have a significant impact on mothers and families. This pilot study investigated the efficacy and safety of oestradiol therapy for PPD.

Exploring Oestrogen Therapy for Postpartum Depression: A New Oasis in the Desert

The study, a double-blind, randomized, placebo-controlled trial, involved 16 mothers in the treatment group and 14 mothers in the placebo group. While the study found no significant difference in the efficacy of oestradiol compared to placebo, it did highlight the importance of managing potential adverse effects, such as irregular bleeding. The study also found that oestradiol did not interfere with breastfeeding.

Navigating the Complexities of Postpartum Depression: A Desert of Diverse Treatment Options

This pilot study provides preliminary evidence regarding the potential benefits and risks of oestradiol therapy for PPD. However, it emphasizes the need for larger, more comprehensive studies to fully evaluate the efficacy and safety of this treatment approach. The study underscores the importance of considering a variety of treatment options for PPD, tailoring interventions to the specific needs of each mother.

Dr.Camel's Conclusion

This pilot study provides valuable insights into the potential benefits and risks of oestradiol therapy for PPD. While the study found no significant difference in efficacy compared to placebo, it highlights the need for further research to explore the optimal use of oestradiol in treating PPD. The findings also emphasize the importance of managing potential adverse effects and considering the individual needs of each mother when choosing a treatment approach.
Date :
  1. Date Completed 2022-07-07
  2. Date Revised 2022-08-01
Further Info :

Pubmed ID

34533410

DOI: Digital Object Identifier

10.1080/08039488.2021.1974556

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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