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Descriptive analysis of reported adverse events associated with anti-obesity medications using FDA Adverse Event Reporting System (FAERS) databases 2013-2020.

Author: AlrasheedMarwan, AlsuhibaniAbdulrahman, GariMusaab, GuoJeff Jianfei, HincapieAna L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Anti-obesity medications (AOMs) are associated with numerous serious adverse events (AEs), including death, life-threatening events, hospitalizations, and disabilities. The analysis of the US FDA Adverse Event Reporting System (FAERS) highlights the need for continuous monitoring of AOMs' safety to optimize patient care.
Paper Details　
Original Abstract of the Article :
Background Obesity is a globally growing health problem, and its treatment has been challenging. The use of anti-obesity medications (AOMs) has been associated with severe adverse events (AEs). Several AOMs have been withdrawn from the market owing to documented AEs. Aim To describe, estimate and ch...See full text at original site
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引用元：
https://doi.org/10.1007/s11096-021-01330-2

データ提供：米国国立医学図書館（NLM）

Anti-Obesity Medications: A Desert of Side Effects

The field of obesity research is a vast and complex one, like a sprawling desert with many hidden dangers. This study delves into the world of anti-obesity medications (AOMs), examining their potential side effects. Using a retrospective analysis of the FDA Adverse Event Reporting System (FAERS), the authors aimed to shed light on the frequency and nature of adverse events (AEs) associated with AOMs. Their findings revealed a significant number of AEs, including serious complications affecting the cardiovascular system and kidneys.

Uncovering the Hidden Dangers of AOMs

The study identified a total of 18,675 unique AEs reports associated with AOMs, highlighting the potential risks associated with these medications. The most frequently reported AEs included nausea and vomiting, dizziness, headaches, and drug ineffectiveness. Furthermore, the study revealed alarmingly high rates of serious outcomes, including 1,039 deaths (fatality ratio of 4.9%), 1,613 life-threatening events, and 7,426 hospitalizations.

Navigating the Desert of Obesity Treatment: Caution and Awareness

These findings emphasize the importance of careful monitoring and evaluation of AOMs. Patients and healthcare providers need to be aware of the potential for serious AEs and closely monitor for any signs or symptoms of concern. While AOMs offer a potential pathway to weight management, it's essential to approach their use with caution and prioritize patient safety.

Dr. Camel's Conclusion

The study serves as a reminder that even in the pursuit of health and well-being, there are risks that must be carefully considered. The desert of obesity treatment is vast and unforgiving, and navigating its challenges requires a keen awareness of potential side effects. It's crucial to work closely with healthcare professionals to weigh the benefits and risks of AOMs and make informed decisions about treatment options.

Date :
  1. Date Completed 2022-02-25
  2. Date Revised 2022-02-25
Further Info :

Pubmed ID

34564826

DOI: Digital Object Identifier

10.1007/s11096-021-01330-2

SNS
PICO Info
in preparation
Languages

English

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