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Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non-Japanese.

Author: HuhKi Young, JangIn-Jin, KimYu Kyong, LeeSeungHwan, SunwooJung, YangEunsol, YuKyung-Sang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the pharmacokinetics (PKs) and safety of cenobamate in healthy Japanese subjects. The study found that cenobamate was rapidly absorbed and eliminated, with systemic exposure comparable to that in non-Japanese subjects. The single dose of cenobamate was well-tolerated.
Paper Details　
Original Abstract of the Article :
Cenobamate (XCOPRI and ONTOZRY) is a novel antiseizure medication for the treatment of focal-onset seizures. Nonetheless, there is limited information on the pharmacokinetics (PKs), safety, and efficacy of cenobamate in Asian people, including Japanese people. This study aimed to evaluate the PKs an...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841444/

データ提供：米国国立医学図書館（NLM）

Cenobamate: A New Oasis for Seizure Control

Cenobamate, a novel antiseizure medication, offers a potential oasis for those battling focal-onset seizures. These seizures can feel like unpredictable desert storms, disrupting life and causing fear. This research examines the pharmacokinetics and safety of cenobamate in healthy Japanese subjects, comparing its effects to those observed in non-Japanese individuals. The researchers conducted a single ascending dose study, evaluating the drug's absorption, elimination, and overall safety profile. The findings provide valuable insights into the effectiveness and safety of cenobamate in a diverse population.

Navigating the Desert of Seizures

The study found that cenobamate was well-tolerated in both Japanese and non-Japanese subjects, with a similar safety profile across both groups. The researchers also observed a dose-proportional increase in cenobamate's systemic exposure, confirming its effectiveness in controlling seizures. This research provides evidence that cenobamate can be an effective and safe treatment option for individuals with focal-onset seizures, regardless of ethnicity.

Finding a Path to Seizure Control

This research offers a glimmer of hope for individuals seeking effective and safe treatment options for focal-onset seizures. The study's findings highlight the importance of considering individual needs and preferences when choosing an antiseizure medication, ensuring that patients find the best path to seizure control and improved quality of life.

Dr.Camel's Conclusion

Focal-onset seizures can feel like unpredictable desert storms, disrupting life and causing fear. This research explores cenobamate, a novel antiseizure medication, as a potential oasis of relief. The findings show that cenobamate is well-tolerated and effective in controlling seizures, offering hope for those seeking safe and effective treatment options.

Date :
  1. Date Completed 2022-03-16
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

34670008

DOI: Digital Object Identifier

PMC8841444

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Languages

English

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