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Effects of Root Extract of <i>Morinda officinalis</i> in Mice with High-Fat-Diet/Streptozotocin-Induced Diabetes and C2C12 Myoblast Differentiation.

Author: JungHyo Won, KangSeok Yong, KimSu Jin, LiuYi, ParkYong-Ki, WangPiao, YinCheng, ZhangTong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The root extract of *Morinda officinalis* (MORE) has shown to be effective in improving diabetes symptoms and muscle function in mice with high-fat-diet (HFD)/streptozotocin (STZ)-induced diabetes. Administration of MORE at 200 mg/kg significantly reduced weight gain, calorie intake, insulin resistance, and serum levels of glucose, total cholesterol (TCHO), LDL-cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) in diabetic mice. In addition, MORE significantly increased the expression of myogenic and biogenesis regulatory proteins, leading to increased muscle fiber size.
Paper Details　
Original Abstract of the Article :
Type 2 diabetes is the most common type of diabetes and causes a decline in muscle quality. In this study, we investigated the effects of the root extract of <i>Morinda officinalis</i> (MORE) on skeletal muscle damage in mice with high-fat-diet (HFD)/streptozotocin (STZ)-induced diabetes and the exp...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529596/

データ提供：米国国立医学図書館（NLM）

Morinda officinalis: A Potential Remedy for Diabetes and Muscle Damage

Type 2 diabetes, a chronic condition affecting blood sugar regulation, can lead to various complications, including muscle damage. This study investigates the potential of Morinda officinalis (MORE), a plant commonly used in traditional medicine, in managing diabetes and improving muscle function. The researchers conducted experiments using mice with high-fat-diet/streptozotocin-induced diabetes, examining the effects of MORE on various metabolic parameters and muscle tissue. The study found that MORE administration significantly improved blood glucose levels, reduced muscle damage, and enhanced the expression of myogenic and biogenesis regulatory proteins, suggesting its potential as a therapeutic agent for diabetes and muscle disorders.

A Natural Approach to Diabetes and Muscle Health

This study provides compelling evidence for the potential of Morinda officinalis as a therapeutic agent for diabetes and muscle disorders. The findings suggest that MORE could effectively improve blood glucose control, reduce muscle damage, and promote muscle regeneration. These findings warrant further investigation to explore the potential of MORE as a complementary or alternative treatment for diabetes and related complications.

Exploring Natural Remedies

This study emphasizes the importance of exploring natural remedies for managing diabetes and related complications. The findings suggest that Morinda officinalis could offer a natural and potentially effective approach to improve blood sugar control and enhance muscle function. It encourages individuals to discuss the potential benefits and risks of natural remedies with their healthcare providers to make informed decisions about their treatment options.

Dr.Camel's Conclusion

This study investigates the potential of Morinda officinalis (MORE) as a therapeutic agent for diabetes and muscle disorders. The findings suggest that MORE could effectively improve blood glucose control, reduce muscle damage, and promote muscle regeneration. While further research is needed to confirm these findings and to develop appropriate treatment protocols, this study highlights the potential of natural remedies in addressing diabetes and related complications.
Date :
  1. Date Completed n.d.
  2. Date Revised 2021-10-26
Further Info :

Pubmed ID

34693116

DOI: Digital Object Identifier

PMC8529596

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Languages

English

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