Effective treatment of herbology: A Synthesis of Findings from 23 Studies

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).

Original Abstract of the Article

Major Research Findings

Several studies suggest that herbs can have therapeutic effects on a variety of health issues, including mental health, metabolic disorders, and inflammation. For example, 3 suggests the potential of herbal therapies for mental health issues like depression, anxiety, and insomnia. Additionally, 6 indicates that Glycyrrhiza uralensis extract can alleviate metabolic disorders in mice with diet-induced obesity. Further, 7 shows that a combination of Gardenia jasminoides and silymarin can improve liver fibrosis in a mouse model. These studies suggest that herbs could be a promising treatment option for various health conditions, but more research is needed to solidify their effectiveness.

Benefits and Risks

Benefits Summary

Herbs have the potential to offer benefits for various health issues, including mental health, metabolic disorders, and inflammation. Specifically, 3 suggests the potential of herbal therapies for mental health issues like depression, anxiety, and insomnia. Additionally, 6 indicates that Glycyrrhiza uralensis extract can alleviate metabolic disorders in mice with diet-induced obesity. Further, 7 shows that a combination of Gardenia jasminoides and silymarin can improve liver fibrosis in a mouse model. These studies suggest that herbs could be a promising treatment option for various health conditions.

Risks Summary

The use of herbs comes with potential risks. Depending on the specific herb and its dosage, there could be interactions with other medications, allergic reactions, digestive issues, or other adverse effects. Moreover, the scientific evidence for the use of many herbs is not yet fully established. Therefore, it is crucial to consult a doctor or pharmacist before using any herbs.

Comparison between Studies

Similarities in Studies

Many studies suggest that herbs have the potential to offer therapeutic effects for various health issues. For instance, research such as 3 , 6 , and 7 points to the potential of herbs for effective treatment of mental health, metabolic disorders, and inflammation. These studies suggest that herbs could be a promising treatment option, but further research is needed.

Differences in Studies

The findings of these studies vary based on the specific types of herbs, their effects, and the research methods employed. For example, 3 highlights the potential of herbal therapies for mental health issues, while 6 focuses on the impact of herbs on metabolic disorders. These differences reflect the diverse range of herbs and their potential effects.

Consistency and Contradictions in Results

The research findings on the effects of herbs show both consistency and contradictions. For instance, 3 , 6 , and 7 suggest that herbs can be effective treatments for various health problems. However, 2 indicates that further research is needed to confirm whether glucosamine and chondroitin have the same effectiveness as celecoxib in osteoarthritis patients. This highlights the need for more extensive research on the effects of herbs.

Practical Implications and Precautions

While herbs could be effective treatments for various health issues, it is crucial to use them safely. Depending on the specific herb and its dosage, there could be interactions with other medications, allergic reactions, digestive issues, or other adverse effects. Moreover, the scientific evidence for the use of many herbs is not yet fully established. Therefore, it is crucial to consult a doctor or pharmacist before using any herbs. Avoid self-treating with herbs and always follow the advice of a healthcare professional.

Limitations of Current Research

The research on the effects of herbs is still limited. Many studies are small-scale, such as animal experiments or cell culture studies. Additionally, the diversity of herbs and their effects makes it difficult to compare research findings. Furthermore, the lack of standardization for the quality and safety of herbs makes it challenging to reproduce research results.

Future Directions for Research

More research on the therapeutic effects of herbs is essential, particularly large-scale clinical trials involving human participants. It is necessary to advance the standardization of the quality and safety of herbs. Research should also focus on understanding the mechanisms by which herbs exert their effects.

Conclusion

Herbs hold potential as therapeutic agents for various health issues. However, the use of herbs can pose risks, so it is essential to utilize them safely. Always consult a healthcare professional before using any herbs. Further research is crucial to solidify the effectiveness and safety of herbs as treatment options.

Keywords

Benefit Keywords

Modest efficacy for OA symptoms

OA symptom relief

Potential disease-modifying effects

Safe treatment

Anti-inflammatory effects

GH+CS

Inflammatory conditions treatment

Potential for joint pain relief

Safer alternative

Mental health treatment

Weed control

Improved diabetes symptoms

Reduced blood glucose

Dyslipidemia treatment

Glucose homeostasis improvement

Inflammation reduction

Obesity treatment

Liver fibrosis treatment

Cartilage protection

OA pain relief

Anti-fibrotic effects

CP treatment

Muscle atrophy treatment

Bone formation

Height growth

Improved diabetes symptoms

Improved muscle function

UR hepatoprotective effect

Anticancer effects

Acute pancreatitis treatment

Anti-neuroinflammatory effects

Antioxidant effects

Reduces esophagus damage

Activation of PPARα

Ameliorative effects on NAFLD

Inhibitory effect on osteoclast differentiation

Weed control

Ulcerative colitis treatment

Diabetic nephropathy treatment

Gut microbiota regulation

Risk Keywords

Further research needed

Limited evidence

Need for further studies

Product variability

Variability in formulation and purity

Needs further research

Unclear effectiveness compared to NSAIDs

Osteoarthritis

Literature analysis of 23 papers

Positive Content

Neutral Content

Negative Content

Article Type

Randomized Controlled Trial1

Meta-Analysis1

Systematic Review0

Review1

Journal Article22

Glucosamine and chondroitin for osteoarthritis?

Author: McAlindonT

Modest efficacy for OA symptoms

OA symptom relief

Potential disease-modifying effects

Safe treatment

Further research needed

Limited evidence

Need for further studies

Product variability

Variability in formulation and purity

Current research suggests that glucosamine and chondroitin provide modest relief for osteoarthritis (OA) symptoms. These supplements are safe and could be helpful for managing OA. However, more independent studies are needed to confirm their effectiveness and determine how they can be used in clinical practice. Physicians face challenges in advising patients due to the wide variation in formulation and purity of available products. While glucosamine and chondroitin might potentially slow OA progression, more research is needed to confirm this and understand their overall impact on OA.

Language : English

Differences in Serum Biomarkers Between Combined Glucosamine and Chondroitin Versus Celecoxib in a Randomized, Double-blind Trial in Osteoarthritis Patients.

Author: NavarroSandi L, HerreroMarta, MartinezHelena, ZhangYuzheng, LaddJon, LoEdward, ShelleyDavid, RandolphTimothy W, LampeJohanna W, LampePaul D

Anti-inflammatory effects

GH+CS

Inflammatory conditions treatment

Potential for joint pain relief

Safer alternative

Needs further research

Unclear effectiveness compared to NSAIDs

Glucosamine hydrochloride plus chondroitin sulfate (GH+CS) is a common supplement for joint pain. While non-steroidal anti-inflammatory drugs (NSAIDs) like celecoxib are also used for joint pain, they can have side effects. Research suggests that GH+CS may have anti-inflammatory properties, offering a potentially safer alternative to NSAIDs.

Language : English

Highs, Lows, and Health Hazards of Herbology: A Review of Herbal Medications with Psychotropic Effects.

Author: Smith-StephensShannon L

Mental health treatment

This article reviews herbal and alternative therapies used to treat anxiety, depression, and insomnia. The review includes indications for use, patient education, and possible interactions with conventional prescribed psychotropic medications.

Language : English

Phytochemical Investigation of Cuscuta campestris Yunck. Stem Extract and Evaluation of Its Bioherbicidal Effect on Amaranthus retroflexus L. and Portulaca oleracea L.

Author: Sarić-KrsmanovićMarija, TojićTeodora, Gajić UmiljendićJelena, ĐorđevićTijana, Đurović-PejčevRada, RadivojevićLjiljana, BožićDragana, VrbničaninSava

Weed control

Stem extract from Cuscuta campestris showed allelopathic and bioherbicidal potential against Amaranthus retroflexus and Portulaca oleracea. The extract inhibited seed germination and early seedling growth at 0.75% and 1%. A synergistic effect with metribuzin herbicide was observed, indicating potential for natural-based weed control.

Language : English

Clean-DM1, a Korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressions in Pancreas and Liver Tissues.

Author: WangPiao, LiuYi, KangSeok Yong, LyuChenzi, HanXiang, HoTianjun, LeeKyung Jae, MengXianglong, ParkYong-Ki, JungHyo Won

Improved diabetes symptoms

Reduced blood glucose

This study investigated the effects of Clean-DM1 (C-DM1), a polyherbal formulation, on high-fat diet (HFD)-induced diabetes mice. The administration of C-DM1 extract significantly decreased body weight, calorie intake, and the levels of blood glucose and insulin in the diabetic mice. C-DM1 extract administration improved the impaired glucose tolerance and insulin resistance in the diabetic mice and significantly decreased the levels of LDL-C, ALT and AST. The C-DM1 extract inhibited the histopathological changes of fatty liver and hyperplasia of pancreatic islets in the diabetic mice. The C-DM1 extract significantly increased the phosphorylation of IRS, AKT, and AMPK and the expression of PI3K in pancreas and liver tissues. These findings suggest that C-DM1 formulation may help prevent the progression of T2DM.

Language : English

The Synergistic Action of Metformin and Glycyrrhiza uralensis Fischer Extract Alleviates Metabolic Disorders in Mice with Diet-Induced Obesity.

Author: HongMin-Kyeong, HanYoungji, ParkHae-Jin, ShinMi-Rae, RohSeong-Soo, KwonEun-Young

Dyslipidemia treatment

Glucose homeostasis improvement

Inflammation reduction

Obesity treatment

This study investigated the synergistic action of metformin and Glycyrrhiza uralensis Fischer (GU) in improving diet-induced obesity in mice. The study found that the combination of metformin and GU (GUM) prevented hepatic steatosis and adiposity, improved dyslipidemia, enhanced glucose homeostasis, and reduced inflammation.

Language : English

Co-Treatments of Gardeniae Fructus and Silymarin Ameliorates Excessive Oxidative Stress-Driven Liver Fibrosis by Regulation of Hepatic Sirtuin1 Activities Using Thioacetamide-Induced Mice Model.

Author: LeeJin A, ShinMi-Rae, ChoiJeongWon, KimMinJu, ParkHae-Jin, RohSeong-Soo

Liver fibrosis treatment

This study evaluated the synergistic effects of Gardeniae Fructus (GF) and silymarin on thioacetamide (TAA)-induced liver fibrosis in a mouse model. The study found that the combination of GF and silymarin (GS) significantly ameliorated liver injury, reduced oxidative stress and DNA damage, and inhibited hepatic stellate cells (HSCs) activation. Further research is needed to understand the specific pharmacological roles of GS.

Language : English

Boswellia serrata Extract, 5-Loxin®, Prevents Joint Pain and Cartilage Degeneration in a Rat Model of Osteoarthritis through Inhibition of Inflammatory Responses and Restoration of Matrix Homeostasis.

Author: ShinMi-Rae, KimHwa-Young, ChoiHwang-Yong, ParkKyoung Sik, ChoiHak Joo, RohSeong-Soo

Cartilage protection

OA pain relief

Osteoarthritis

This study explored the therapeutic potential of 5-Loxin, a standardized Boswellia serrata extract, in a rat model of osteoarthritis (OA). The study found that 5-Loxin effectively relieved OA joint pain by inhibiting inflammatory processes and cartilage degeneration. The findings suggest that 5-Loxin may serve as a potential therapeutic agent for the treatment of OA.

Language : English

Arecae pericarpium water extract alleviates chronic pancreatitis by deactivating pancreatic stellate cells.

Author: KweonBitna, KimDong-Uk, OhJin-Young, OhHyuncheol, KimYoun-Chul, MunYeun-Ja, BaeGi-Sang, ParkSung-Joo

Anti-fibrotic effects

CP treatment

This study investigates the anti-fibrotic effects of Arecae pericarpium (ARP) in a cerulein-induced chronic pancreatitis (CP) model. ARP treatment significantly reduced inflammation, improved glandular atrophy, and repressed collagen deposition by inhibiting TGF-β/Smad signaling.

Language : English

10.

Gardeniae Fructus Extract Alleviates Dexamethasone-Induced Muscle Atrophy in Mice.

Author: LeeJin A, LeeSe Hui, ShinMi-Rae, ParkHae-Jin, RohSeong-Soo

Muscle atrophy treatment

This study investigated the effects of Gardeniae Fructus (GF) hot water extract on dexamethasone (DEX)-induced muscle atrophy (MA) in mice. GF treatment was found to significantly improve muscle weight, swimming performance, and oxidative stress markers. These findings suggest that GF may be a potential therapeutic agent for MA.

Language : English

11.

Effects of Astragalus Extract Mixture HT042 on Circulating IGF-1 Level and Growth Hormone Axis in Rats.

Author: LeeDonghun, KimByung-Hak, LeeSung-Hyun, ChoWon-Young, KimYoung-Sik, KimHocheol

Bone formation

Height growth

Astragalus extract mixture HT042 increased circulatory IGF-1 levels, stimulated GH secretion through modulation of GHRH-R and GHS-R in the pituitary, and promoted bone formation in cartilage. The growth-promoting effect of HT042 was mediated by GH/IGF-1 pathways, suggesting its potential for promoting children's height growth.

Language : English

12.

Effects of Root Extract of Morinda officinalis in Mice with High-Fat-Diet/Streptozotocin-Induced Diabetes and C2C12 Myoblast Differentiation.

Author: WangPiao, LiuYi, ZhangTong, YinCheng, KangSeok Yong, KimSu Jin, ParkYong-Ki, JungHyo Won

Improved diabetes symptoms

Improved muscle function

The root extract of *Morinda officinalis* (MORE) has shown to be effective in improving diabetes symptoms and muscle function in mice with high-fat-diet (HFD)/streptozotocin (STZ)-induced diabetes. Administration of MORE at 200 mg/kg significantly reduced weight gain, calorie intake, insulin resistance, and serum levels of glucose, total cholesterol (TCHO), LDL-cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) in diabetic mice. In addition, MORE significantly increased the expression of myogenic and biogenesis regulatory proteins, leading to increased muscle fiber size.

Language : English

13.

Effects of Jowiseungki-tang on high fat diet-induced obesity in mice and functional analysis on network pharmacology and metabolomics analysis.

Author: MengXianglong, YanJingning, MaJunnan, KangAn Na, KangSeok Yong, ZhangQi, LyuChenzi, ParkYong-Ki, JungHyo Won, ZhangShuosheng

Jowiseungki-tang (JST), a traditional Chinese and Korean medicine prescription for diabetes mellitus (DM), was found to significantly reduce body weight gain, insulin levels, cholesterol, triglycerides, and inflammation in HFD-induced obese mice.

Language : English

14.

Effect of Uncaria rhynchophylla against Thioacetamide-Induced Acute Liver Injury in Rat.

Author: ShinMi-Rae, KimMin Ju, LeeJin A, RohSeong-Soo

ALI treatment

UR hepatoprotective effect

Uncaria rhynchophylla (UR) was found to ameliorate thioacetamide- (TAA-) induced acute liver injury (ALI) in rats by suppressing oxidative stress (OS) and inflammation. UR significantly reduced liver enzyme levels and improved liver tissue lesions.

Language : English

15.

Anticancer Effects of Ursi Fel Extract and Its Active Compound, Ursodeoxycholic Acid, in FRO Anaplastic Thyroid Cancer Cells.

Author: JungHyo Won, HwangJi Hye

Anticancer effects

This study found that Ursi Fel (UF) extract and its active compound, ursodeoxycholic acid (UDCA), exhibit anticancer properties in human anaplastic thyroid cancer cells (FRO). UF extract and UDCA inhibited cell growth, induced apoptosis, and inhibited angiogenesis by regulating the Akt/mTOR signaling pathway.

Language : English

16.

Betulinic Acid Ameliorates the Severity of Acute Pancreatitis via Inhibition of the NF-κB Signaling Pathway in Mice.

Author: ZhouZiqi, ChoiJi-Won, ShinJoon Yeon, KimDong-Uk, KweonBitna, OhHyuncheol, KimYoun-Chul, SongHo-Joon, BaeGi-Sang, ParkSung-Joo

Acute pancreatitis treatment

Acute pancreatitis (AP) is a serious condition that causes inflammation of the pancreas. There are limited treatments for AP. The study found that betulinic acid (BA), a compound found in birch bark, can reduce the severity of AP in mice. BA works by reducing inflammation and inhibiting a signaling pathway called NF-kappaB.

Language : English

17.

Chemical Analysis of the Ingredients of 20% Aqueous Ethanol Extract of Nardostachys jatamansi through Phytochemical Study and Evaluation of Anti-Neuroinflammatory Component.

Author: KimKwan-Woo, YoonChi-Su, ParkSung-Joo, BaeGi-Sang, KimDong-Gu, KimYoun-Chul, OhHyuncheol

Anti-neuroinflammatory effects

This study investigates the potential of Nardostachys jatamansi (NJ20) extract as a botanical drug for treating neuroinflammatory diseases. The study identifies desoxo-narchinol A as the major constituent of NJ20, which demonstrates anti-neuroinflammatory effects by inhibiting the production of proinflammatory mediators.

Language : English

18.

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats.

Author: LeeJin A, ShinMi-Rae, KimMin Ju, LeeJi Hye, ParkHae-Jin, RohSeong-Soo

Antioxidant effects

Reduces esophagus damage

Curcumae longae Rhizoma 30% EtOH extract (CLR) was found to have a protective effect against acute reflux esophagitis in rats by reducing tissue damage, inflammation, and oxidative stress.

Language : English

19.

Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease.

Author: ShinMi-Rae, ShinSung Ho, RohSeong-Soo

Activation of PPARα

Ameliorative effects on NAFLD

A combination of Diospyros kaki fruit and Citrus unshiu peel mixture (PCM) effectively attenuated nonalcoholic fatty liver disease (NAFLD) in mice. PCM activated AMPK, increased PPARα, and inhibited SREBPs expression, leading to improved liver damage and reduced NAFLD.

Language : English

20.

Aqueous extract of Chrysanthemum morifolium Ramat. inhibits RANKL-induced osteoclast differentiation by suppressing the c-fos/NFATc1 pathway.

Author: JangHye-Yeon, LeeHwa-Suk, NohEun-Mi, KimJeong-Mi, YouYong-Ouk, LeeGuemsan, KooJeung-Hyun, LimHyungsun, KoSeonghoon, KimJong-Suk, LeeJun Ho, LeeYoung-Rae

Inhibitory effect on osteoclast differentiation

Chrysanthemum morifolium Ramat. is a plant with various medicinal benefits. This study explores the potential of chrysanthemum extract to inhibit the differentiation of osteoclasts, bone-resorbing cells, which may help to prevent bone loss.

Language : English

21.

Effects of mixtures of allelopathic plant water extracts and a herbicide on weed suppression.

Author: Sarić-KrsmanovićMarija M, RadivojevićLjiljana M, ŠantrićLjiljana R, ĐorđevićTijana M, Gajić UmiljendićJelena S

Weed control

Water extracts of Ambrosia artemisiifolia and Xanthium strumarium, combined with the herbicide mesotrione, were found to be effective in inhibiting the growth of Abutilon theophrasti and Chenopodium album. The combination treatment resulted in over 90% inhibition of fresh weight, over 80% inhibition of pigments content, and over 70% inhibition of plant height.

Language : English

22.

New approach of medicinal herbs and sulfasalazine mixture on ulcerative colitis induced by dextran sodium sulfate.

Author: ShinMi-Rae, ParkHae-Jin, SeoBu-Il, RohSeong-Soo

Ulcerative colitis treatment

This study highlights the need for new treatment strategies for ulcerative colitis, a chronic inflammatory bowel disease. Sulfasalazine, a standard-of-care drug, causes significant adverse effects. The research calls for the development of new therapies that enhance pharmacological efficacy while minimizing side effects.

Language : English

23.

A Novel Approach Based on Metabolomics Coupled With Intestinal Flora Analysis and Network Pharmacology to Explain the Mechanisms of Action of Bekhogainsam Decoction in the Improvement of Symptoms of Streptozotocin-Induced Diabetic Nephropathy in Mice.

Author: MengXianglong, MaJunnan, KangAn Na, KangSeok Yong, JungHyo Won, ParkYong-Ki

Diabetic nephropathy treatment

Gut microbiota regulation

This study found that Bekhogainsam decoction (BHID) ameliorated diabetic nephropathy (DN) in mice. BHID prevented physiological and serological changes, structural damage, and kidney dysfunction by affecting the gut microbiota and acting through phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) and MAPK-related protein targets.

Language : English

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