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Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function.
Author: DaveSandeep, GinsburgGeoffrey S, MyersRachel A, OrtelThomas L, VooraDeepak, WaldropAlexander
Original Abstract of the Article :
Aspirin has known effects beyond inhibiting platelet cyclooxygenase-1 (COX-1) that have been incompletely characterized. Transcriptomics can comprehensively characterize the on- and off-target effects of medications. We used a systems pharmacogenomics approach of aspirin exposure in volunteers coupl...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/34705291
データ提供:米国国立医学図書館(NLM)
Aspirin: A Complex Medication with Unforeseen Effects
Aspirin, a familiar remedy, is often used to prevent cardiovascular disease. However, its effects go beyond inhibiting platelet COX-1, impacting the platelet transcriptome in a complex manner. This research explores the dose-independent effects of aspirin on platelet gene expression and its paradoxical association with increased platelet function. It's like discovering a hidden oasis in the desert that appears to have both refreshing and disorienting effects.
Aspirin's Impact on Platelet Gene Expression: A Paradoxical Effect
The study reveals that aspirin alters the platelet transcriptome, leading to an unexpected increase in platelet function despite its known antiplatelet effects. This suggests that aspirin's actions are more complex than previously understood. It's like finding a mirage that seems to refresh you but also leaves you feeling slightly off balance.
Aspirin and Platelet Function
Understanding aspirin's complex effects on platelet gene expression is crucial for optimizing its use in cardiovascular disease prevention and treatment. It's important to carefully consider the potential benefits and risks, as aspirin's actions might not always be straightforward. It's like navigating a desert oasis that appears to have both benefits and drawbacks, requiring careful assessment before venturing in.
Dr.Camel's Conclusion
This research reveals a dose-independent effect of aspirin on platelet gene expression, leading to a paradoxical increase in platelet function. This discovery highlights the complexity of aspirin's actions and underscores the importance of understanding its multifaceted effects.
Date :
- Date Completed 2022-04-12
- Date Revised 2023-05-02
Further Info :
Related Literature
English
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