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Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis.

Author: BohneLoryn J, DoreyTristan W, JansenHailey J, JonesDouglas L, LiuYingjie, RoseRobert A, TuomiJari M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ibrutinib and acalabrutinib are Bruton tyrosine kinase inhibitors used in the treatment of B-cell lymphoproliferative disorders. This study found that ibrutinib and acalabrutinib have distinct effects on atrial electrophysiology and ion channel function, which may explain why ibrutinib is associated with atrial fibrillation and sinus bradycardia, while acalabrutinib is less arrhythmogenic.
Paper Details　
Original Abstract of the Article :
Background Ibrutinib and acalabrutinib are Bruton tyrosine kinase inhibitors used in the treatment of B-cell lymphoproliferative disorders. Ibrutinib is associated with new-onset atrial fibrillation. Cases of sinus bradycardia and sinus arrest have also been reported following ibrutinib treatment. C...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751944/

データ提供：米国国立医学図書館（NLM）

Distinct Effects of Bruton Tyrosine Kinase Inhibitors on Cardiac Electrophysiology

This research delves into the distinct effects of two Bruton tyrosine kinase (BTK) inhibitors, ibrutinib and acalabrutinib, on cardiac electrophysiology, specifically focusing on atrial fibrillation susceptibility and sinoatrial node (SAN) function. The study aims to understand the mechanisms underlying the different arrhythmogenic profiles of these two drugs. The authors found that [specific findings about the effects of ibrutinib and acalabrutinib on cardiac electrophysiology]. These findings provide valuable insights into the potential cardiac risks associated with BTK inhibitors and inform clinical decision-making.

Navigating the Cardiac Risks of Bruton Tyrosine Kinase Inhibitors

The study's findings highlight the importance of considering the potential cardiac risks associated with BTK inhibitors. The research reveals that ibrutinib may be associated with a higher risk of atrial fibrillation compared to acalabrutinib. Clinicians should be aware of these potential risks and monitor patients closely for cardiac abnormalities during treatment.

Cardiac Safety and Bruton Tyrosine Kinase Inhibitors

This research underscores the importance of understanding the distinct effects of different BTK inhibitors on cardiac electrophysiology. It emphasizes the need for careful patient selection, close monitoring, and tailored treatment approaches to minimize the potential cardiac risks associated with these drugs.

Dr.Camel's Conclusion

This research provides a detailed analysis of the distinct effects of two Bruton tyrosine kinase (BTK) inhibitors on cardiac electrophysiology. The study reveals that ibrutinib may be associated with a higher risk of atrial fibrillation compared to acalabrutinib. These findings highlight the importance of considering the potential cardiac risks of BTK inhibitors and emphasize the need for careful patient selection and close monitoring.

Date :
  1. Date Completed 2022-03-03
  2. Date Revised 2022-03-03
Further Info :

Pubmed ID

34726066

DOI: Digital Object Identifier

PMC8751944

Related Literature

Article Analysis
・Effects of ibrutinib
SNS
PICO Info
in preparation
Languages

English

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