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Lithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar Disorder: A Randomized Clinical Trial.

Author: , AhearnEileen, BoneyTamara Y, ConradChester H, DeLisiLynn E, DorosGheorghe, FergusonRyan, HoffmanBrian, HolmbergErika F, HuangGrant D, KatzIra R, KaufmanJames S, LewRobert, LiangMatthew H, OstacherMichael J, PaikJulie M, RingerRobert J, RogersMalcolm P, SmithEric G, ThwinSoe Soe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Lithium augmentation of usual care did not reduce the incidence of suicide-related events in veterans with major depression or bipolar disorders who experienced a recent suicide event.
Paper Details　
Original Abstract of the Article :
IMPORTANCE: Suicide and suicide attempts are persistent and increasing public health problems. Observational studies and meta-analyses of randomized clinical trials have suggested that lithium may prevent suicide in patients with bipolar disorder or depression. OBJECTIVE: To assess whether lithium ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600458/

データ提供：米国国立医学図書館（NLM）

Lithium: A Promising Solution for Preventing Suicide-Related Events?

Suicide and suicide attempts are serious public health concerns, casting a shadow over our communities. This study investigates the potential of lithium augmentation to reduce the occurrence of repeated suicide-related events in veterans with major depression or bipolar disorder. The researchers conducted a double-blind, placebo-controlled randomized clinical trial to assess the effectiveness of lithium in preventing future suicide-related events. The study analyzed data from a large group of veterans who had recently experienced a suicide-related event.

Lithium's Role in Suicide Prevention: A Complex Picture

The study found no significant difference in the rate of repeated suicide-related events between those receiving lithium and those receiving placebo. While lithium has shown promise in some observational studies and meta-analyses, this clinical trial suggests that simply adding lithium to existing treatment regimens may not be sufficient to prevent a broad range of suicide-related events in individuals with mood disorders and complex medical histories.

Navigating the Labyrinth of Mental Health Care

Mental health is a complex and multifaceted aspect of our well-being. Preventing suicide requires a comprehensive and personalized approach that addresses the unique needs of each individual. While lithium may play a role in certain cases, a multidisciplinary approach involving mental health professionals, family support, and ongoing monitoring is essential for long-term well-being.

Dr. Camel's Conclusion

This study reveals that lithium augmentation, while promising in previous studies, did not reduce the incidence of suicide-related events in veterans with major depression or bipolar disorder. A more comprehensive and individualized approach to mental health care is crucial for suicide prevention.

Date :
  1. Date Completed 2022-02-21
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

34787653

DOI: Digital Object Identifier

PMC8600458

Related Literature

Article Analysis
・Effective treatment of suicide
SNS
PICO Info
in preparation
Languages

English

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