Paper Details

  1. Home
  2. Paper Details

Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish.

Author: BednarzKinga, MaciagMonika, PlazinskaAnita, WnorowskiArtur

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the potential of zebrafish as a model for cardiovascular research, particularly in the development of heart failure models. The researchers tested various beta-adrenergic (βAR) agonists, finding that epinephrine significantly stimulated heart rate at low concentrations but caused severe heart rate inhibition at higher concentrations, indicating its potential for inducing heart failure. Isoetharine, another βAR agonist, led to body pigmentation loss at sublethal doses, suggesting its potential for creating a transparent zebrafish model. The study also showed that zebrafish heart rate responds to βAR antagonists similarly to humans, validating the zebrafish model's ability to mimic human cardiac physiology.
Paper Details　
Original Abstract of the Article :
Cardiovascular toxicity represents one of the most common reasons for clinical trial failure. Consequently, early identification of novel cardioprotective strategies could prevent the later-stage drug-induced cardiac side effects. The use of zebrafish (Danio rerio) in preclinical studies has greatly...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.taap.2021.115812

データ提供：米国国立医学図書館（NLM）

Zebrafish: A New Frontier in Cardiovascular Research

This research explores the potential of zebrafish as a model organism for studying cardiovascular toxicity. The authors investigate the use of various β-adrenergic ligands to develop pharmacological models of heart failure in zebrafish, seeking to enhance the preclinical testing of drugs to identify potential cardiac side effects.

Zebrafish: A Tiny Model with Big Potential

This research highlights the versatility of zebrafish as a model organism in biomedical research. The authors demonstrate the feasibility of using zebrafish to study cardiovascular toxicity, potentially leading to more efficient drug development and safer medications.

Protecting the Heart: A Multi-pronged Approach

This research underscores the importance of comprehensive cardiovascular research. By exploring the potential of zebrafish as a model organism, we can develop more efficient and accurate methods for assessing drug toxicity and identifying potential cardioprotective strategies.

Dr.Camel's Conclusion

Imagine a desert with a vast and diverse ecosystem. This research is like a magnifying glass, allowing us to examine the delicate intricacies of the cardiovascular system in a new model organism. Zebrafish offer a promising tool for understanding the complexities of heart health and advancing the development of safe and effective treatments.

Date :
  1. Date Completed 2022-02-18
  2. Date Revised 2022-02-18
Further Info :

Pubmed ID

34838787

DOI: Digital Object Identifier

10.1016/j.taap.2021.115812

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.