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Systematic review with meta-analysis: the impact of functional cure on clinical outcomes in patients with chronic hepatitis B.

Author: AuhSungyoung, GhanyMarc G, HuAlvin, MajeedNehna A, SharmaDisha, TerryNancy, VittalAnusha

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review assessed the impact of hepatitis B surface antigen (HBsAg) loss on clinical outcomes in chronic hepatitis B virus (HBV) infection. HBsAg loss was associated with a reduced risk of hepatocellular carcinoma (HCC), incident cirrhosis, hepatic decompensation, and mortality. However, more research is needed to confirm these findings.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Although hepatitis B surface antigen (HBsAg) loss is considered the ideal therapeutic endpoint for the treatment of chronic hepatitis B virus (HBV) infection, its impact on clinical outcomes remains uncertain. AIM: To assess the impact of HBsAg loss on clinical outcomes following sponta...See full text at original site
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引用元：
https://doi.org/10.1111/apt.16659

データ提供：米国国立医学図書館（NLM）

The Quest for a Functional Cure for Chronic Hepatitis B

The realm of hepatitis B research is constantly striving for better treatments and a deeper understanding of this complex viral infection. This study delves into the impact of HBsAg loss, often considered the ideal therapeutic endpoint, on clinical outcomes in patients with chronic hepatitis B.

HBsAg Loss: A Beacon of Hope?

The researchers conducted a comprehensive analysis of studies investigating the link between HBsAg loss and clinical outcomes. While the results suggest that HBsAg loss is associated with a reduced risk of complications, the study acknowledges that further research is needed to establish definitive conclusions. It's like searching for a hidden oasis in the vast desert of hepatitis B – the path to a functional cure remains a journey of discovery.

Understanding the Nuances of HBsAg Loss

The study reveals that the impact of HBsAg loss can vary based on individual factors, such as gender, underlying cirrhosis, and family history of HCC. This underscores the importance of personalized medicine and the need for tailored approaches to treatment.

Dr.Camel's Conclusion

The search for a functional cure for chronic hepatitis B continues. This study provides valuable insights, highlighting the potential benefits of HBsAg loss while acknowledging the need for further research. Like a camel traversing a challenging desert, researchers are making progress in understanding and treating this complex disease, offering hope for a brighter future for those affected.

Date :
  1. Date Completed 2022-02-02
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

34850415

DOI: Digital Object Identifier

10.1111/apt.16659

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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