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Impact of Donepezil and Memantine on Behavioral and Psychological Symptoms of Alzheimer Disease: Six-month Open-label Study.

Author: BadžakJasna, Bago RožankovićPetra, RožankovićMarjan, StojićMaristela, Šušak SporišIvana

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Both donepezil and memantine were effective in treating behavioral and psychological symptoms of dementia (BPSD) in individuals with moderate Alzheimer disease (AD). Both treatments resulted in significant improvements in most domains of the Neuropsychiatric Inventory (NPI), except for euphoria and apathy, which did not show improvement with memantine.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are common in individuals with Alzheimer disease (AD). Donepezil and memantine are both widely used for the treatment of moderate AD. OBJECTIVE: To evaluate the effects of donepezil and memantine in relieving BPSD in individuals w...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34851866

データ提供：米国国立医学図書館（NLM）

Donepezil and Memantine: Easing Behavioral and Psychological Symptoms of Alzheimer's Disease

The challenges faced by individuals with [Alzheimer's disease (AD)] extend beyond cognitive decline, often including [behavioral and psychological symptoms of dementia (BPSD)]. This research investigates the effectiveness of [donepezil] and [memantine], two commonly prescribed medications for [moderate AD], in alleviating [BPSD]. The study analyzed data from a [6-month open-label study] involving 85 individuals with [moderate AD].

A Ray of Hope: Donepezil and Memantine Show Promise in Managing BPSD

The study found that both [donepezil] and [memantine] led to significant improvements in [BPSD] severity, as measured by the [Neuropsychiatric Inventory (NPI)]. Both treatments demonstrated improvement across most [NPI domains], suggesting a potential benefit for managing a wide range of [BPSD]. Furthermore, both medications were well tolerated, with minimal side effects. These findings provide evidence that [donepezil] and [memantine] may offer a valuable approach to managing [BPSD] in individuals with [moderate AD].

Dr.Camel's Conclusion

This study offers valuable insights into the management of [BPSD] in individuals with [Alzheimer's disease]. It provides evidence that [donepezil] and [memantine], while primarily used for [cognitive impairment], may also play a role in alleviating [BPSD] and improving the overall quality of life for patients. As always, the choice of treatment should be made in consultation with a healthcare professional, taking into account individual patient factors and potential risks.

Date :
  1. Date Completed 2022-01-25
  2. Date Revised 2023-09-25
Further Info :

Pubmed ID

34851866

DOI: Digital Object Identifier

00146965-202112000-00004

Related Literature

Article Analysis
・Effective treatment of dementia
SNS
PICO Info
in preparation
Languages

English

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