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Synergistic cortisol suppression by ketoconazole-osilodrostat combination therapy.

Author: AmodruVincent, BrueThierry, CastinettiFrederic

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study reports on a patient with Cushing's syndrome, a condition caused by too much cortisol. The patient did not respond well to treatment with ketoconazole or osilodrostat. However, combining these two drugs was successful in controlling the patient's cortisol levels.
Paper Details　
Original Abstract of the Article :
Here, we describe a case of a patient presenting with adrenocorticotrophic hormone-independent Cushing's syndrome in a context of primary bilateral macronodular adrenocortical hyperplasia. While initial levels of cortisol were not very high, we could not manage to control hypercortisolism with ketoc...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686175/

データ提供：米国国立医学図書館（NLM）

Combination Therapy for Cushing's Syndrome: A Novel Approach

This research explores the intricate landscape of Cushing's syndrome, a condition that can be as disruptive as a sandstorm sweeping across the desert. The study investigates the use of a combination therapy involving ketoconazole and osilodrostat to control hypercortisolism in a patient with Cushing's syndrome. The researchers describe a case study of a patient who was successfully treated with this combination therapy, highlighting its potential as a novel approach for managing this challenging condition.

A Combined Effort: Navigating the Challenges of Cushing's Syndrome

This study highlights the potential of a combination therapy involving ketoconazole and osilodrostat to control hypercortisolism in individuals with Cushing's syndrome. The researchers demonstrate the effectiveness of this approach in a case study, offering hope for individuals seeking to manage this challenging condition.

A New Pathway for Treatment

This research explores a novel approach to managing Cushing's syndrome. The study's findings suggest that a combination therapy involving ketoconazole and osilodrostat may offer a promising alternative for individuals who have not responded well to other treatment options. It's a testament to the ongoing search for innovative solutions to the challenges we face in healthcare.

Dr.Camel's Conclusion

This research showcases the potential of combination therapy involving ketoconazole and osilodrostat in managing Cushing's syndrome. The study's findings offer a glimmer of hope for individuals struggling with this challenging condition, highlighting the importance of exploring novel treatment approaches to address unmet medical needs. It's a reminder that the search for effective treatments is an ongoing journey, with new discoveries and innovations emerging constantly.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-29
Further Info :

Pubmed ID

34877930

DOI: Digital Object Identifier

PMC8686175

Related Literature

Article Analysis
・Side Effects of ketoconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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