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Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis.

Author: ArmstrongApril W, BagelJerry, BissonnetteRobert, BrownPhilip M, EhstBenjamin, FromowitzJeff, GuenthnerScott, HongH Chih-Ho, KircikLeon, LebwohlMark G, PappKim A, PiscitelliStephen C, RubensteinDavid S, SoungJennifer, Stein GoldLinda, StroberBruce, TallmanAnna M

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Two phase 3 trials evaluated the efficacy and safety of tapinarof 1% cream for treating plaque psoriasis. Tapinarof demonstrated significantly greater improvement in psoriasis severity compared to vehicle control after 12 weeks. However, local adverse events and headache were reported. Further research is needed to compare tapinarof with existing treatments.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Tapinarof cream is a topical aryl hydrocarbon receptor-modulating agent under investigation for the treatment of psoriasis. Tapinarof modulates the expression of interleukin-17 and the skin-barrier proteins filaggrin and loricrin. METHODS: We conducted two identical phase 3 randomized t...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa2103629

データ提供：米国国立医学図書館（NLM）

Tapinarof Cream for Plaque Psoriasis

Psoriasis is a chronic skin condition, like a stubborn desert sandstorm that refuses to settle. This research investigates the efficacy and safety of tapinarof cream, a novel topical treatment for plaque psoriasis. The authors conducted two identical phase 3 randomized controlled trials to compare the effectiveness of tapinarof cream to a vehicle control in patients with mild to severe plaque psoriasis. Their study provides valuable insights into the potential benefits and risks of this new treatment option.

Tapinarof Cream: A Promising New Treatment?

The study found that tapinarof cream was significantly superior to vehicle control in reducing the severity of plaque psoriasis over a 12-week period. A higher proportion of patients treated with tapinarof achieved a clear or almost clear skin response and experienced significant improvements in their psoriasis symptoms. These results suggest that tapinarof cream may offer a valuable new treatment option for patients with plaque psoriasis.

Implications for Psoriasis Treatment and Skin Health

This research highlights the potential of tapinarof cream as a new treatment option for plaque psoriasis. The study's findings suggest that tapinarof cream may offer a valuable new treatment option for patients with plaque psoriasis, potentially improving their quality of life and reducing the impact of this chronic skin condition. However, further research is needed to confirm these findings and explore the long-term efficacy and safety of tapinarof cream in treating psoriasis. Like a camel seeking relief from the desert sun, patients with psoriasis need effective treatments to manage their symptoms and improve their quality of life.

Dr.Camel's Conclusion

This research provides a glimmer of hope in the desert of psoriasis, suggesting that tapinarof cream may offer a new and effective treatment option. Further research is crucial to confirm these findings and explore the long-term benefits of this promising therapy.

Date :
  1. Date Completed 2021-12-23
  2. Date Revised 2021-12-23
Further Info :

Pubmed ID

34879448

DOI: Digital Object Identifier

10.1056/NEJMoa2103629

Related Literature

Article Analysis
・Effects of tapinarof topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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