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Hypoglycemia associated with direct-acting anti-hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS).

Author: ChenZhou, LiuLibin, WangXiaolu, XieWenhuo, ZhengChenhua, ZhouYu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examined the hypoglycemic safety signal for direct-acting antiviral agents (DAAs) used for chronic hepatitis C virus infection using the US Food and Drug Administration Adverse Event Reporting System (FAERS). DAAs were associated with an increased reporting risk of hypoglycemia, particularly telaprevir and elbasvir/grazoprevir. This risk was heightened when DAAs were combined with insulins and sulfonylureas.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND OBJECTIVE: Hypoglycemia induced by direct-acting antiviral agents (DAAs) for chronic hepatitis C virus (HCV) infection is a rare but potentially life-threatening adverse reaction, which led to warnings by competent authorities. We therefore aimed to examine the hypoglycemic safety sig...See full text at original site
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引用元：
https://doi.org/10.1111/cen.14660

データ提供：米国国立医学図書館（NLM）

Hypoglycemia Risk With Direct-Acting Anti-Hepatitis C Virus Drugs

This study explores the potential risks associated with direct-acting antiviral agents (DAAs) used to treat chronic hepatitis C virus (HCV) infection. While DAAs are highly effective in combating HCV, they can occasionally lead to a rare but potentially serious adverse effect: hypoglycemia (low blood sugar). This study delves into the safety signal for DAAs, analyzing data from the US Food and Drug Administration Adverse Event Reporting System (FAERS).

DAAs and Hypoglycemia: A Complex Relationship

The study reveals a potential increased risk of hypoglycemia associated with DAA use, particularly in HCV patients with diabetes. While the overall risk is still relatively low, the study highlights the need for caution and vigilant monitoring, especially when combining DAAs with certain antidiabetic medications like insulins and sulfonylureas. This research contributes to our understanding of DAA-associated risks and provides valuable insights for clinical practice.

Navigating Hepatitis C Treatment: Balancing Benefits and Risks

Hepatitis C treatment has undergone a remarkable transformation with the advent of DAAs, offering highly effective and well-tolerated options. However, this study reminds us that even the most promising treatments can have potential risks. It's like navigating a desert oasis—while the water is refreshing, it's essential to be aware of potential hazards and take precautions. This research underscores the importance of carefully balancing the benefits and risks of DAA therapy for patients with HCV.

Dr.Camel's Conclusion

This study highlights a potential hypoglycemic risk associated with DAA use, particularly in patients with diabetes. It's like discovering a hidden sandstorm in the desert of HCV treatment—a potential hazard to be aware of and mitigate. This research emphasizes the importance of close monitoring and careful management of hypoglycemia in patients receiving DAA therapy.
Date :
  1. Date Completed 2022-04-05
  2. Date Revised 2022-07-14
Further Info :

Pubmed ID

34913180

DOI: Digital Object Identifier

10.1111/cen.14660

Related Literature

Article Analysis
・Effects of elbasvir and grazoprevir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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