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Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1α signaling.

Author: ChenTianpeng, HuWenfeng, LiBingda, LiPing, WangZhenhua, WuJi, ZhouQing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Poncirin, a compound found in bitter orange, has antioxidant effects. In this study, poncirin was found to protect heart cells from damage caused by lack of oxygen.
Paper Details　
Original Abstract of the Article :
Poncirin, a flavonoid glycoside derivative extracted from the fruits of Poncirus trifoliata (trifoliate orange or Chinese bitter orange), has a variety of documented bioactivities, including anti-tumor, anti-inflammatory, and antioxidant effects. Oxidative stress is a major underlying factor in the ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejphar.2022.174759

データ提供：米国国立医学図書館（NLM）

Poncirin: A Potential Protector Against Cardiac Ischemia-Reperfusion Injury

In the complex world of [cardiovascular health], researchers are constantly seeking ways to mitigate the devastating effects of [cardiac ischemia-reperfusion (I/R) injury]. This study investigates the potential protective effects of [poncirin], a [flavonoid glycoside derivative], against [cardiac I/R injury]. Using both [in vitro] and [in vivo] models, the researchers discovered that [poncirin] effectively reduced [cardiomyocyte apoptosis] and [infarct size] by mitigating [oxidative stress]. They further identified the [PI3K/AKT/PGC-1α pathway] as the key mechanism responsible for these protective effects.

The Power of Poncirin

This research sheds light on the potential of [poncirin] as a [cardioprotective agent]. The findings suggest that [poncirin] can effectively combat [oxidative stress], a major contributor to [cardiac I/R injury], by activating the [PI3K/AKT/PGC-1α pathway]. This discovery opens doors for further investigation into the potential therapeutic applications of [poncirin] in preventing and treating [cardiac I/R injury].

Harnessing Nature's Healing Power

Just as a camel adapts to the harsh desert environment, so too can we harness nature's bounty for our own health. This study provides evidence for the potential of [poncirin], a natural compound, to protect against [cardiac I/R injury]. It reminds us of the importance of exploring natural sources for potential medical treatments.

Dr. Camel's Conclusion

This study suggests that poncirin holds promise as a cardioprotective agent against cardiac ischemia-reperfusion injury. Further research is needed to explore its potential therapeutic applications.
Date :
  1. Date Completed 2022-03-23
  2. Date Revised 2022-03-23
Further Info :

Pubmed ID

35032487

DOI: Digital Object Identifier

10.1016/j.ejphar.2022.174759

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Article Analysis
・Effective treatment of bitter orange
SNS
PICO Info
in preparation
Languages

English

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