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Naloxegol and Postoperative Urinary Retention: A Randomized Trial.

Author: ChelnickDavid, EsaWael Ali Sakr, FangJonathan, HamadnallaHassan, LeungSteve, Mounir SolimanLoran, PuXuan, RazaSyed, RuetzlerKurt, SeifJohn, SesslerDaniel I, TuranAlparslan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This randomized controlled trial investigated the effect of naloxegol on opioid-induced bladder dysfunction following hip and knee surgery. The study found no significant difference in residual urine volume between the naloxegol and placebo groups. Therefore, the authors concluded that naloxegol is not recommended for the treatment of postoperative urinary retention.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. HYPOTHESIS: patients given naloxegol have lower residual bladder urine volume than those give...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780376/

データ提供：米国国立医学図書館（NLM）

Naloxegol and Postoperative Urinary Retention: A Research Journey

Our journey takes us to the realm of postoperative pain management. This study investigates the potential of naloxegol, a medication designed to reduce opioid-related side effects, in addressing postoperative urinary retention. It's like exploring a new desert, searching for a solution to a common post-surgical challenge.

Naloxegol's Effectiveness: A Question of Impact

The study, a comprehensive exploration of naloxegol's impact on postoperative urinary retention, found no significant difference in residual bladder urine volume between patients receiving naloxegol and those receiving placebo. This suggests that naloxegol may not be effective in addressing opioid-induced bladder dysfunction. It's like finding an oasis in a desert, only to discover it's just a mirage.

The Search for Effective Solutions Continues

While this study's findings may not be conclusive, it offers valuable insights into the ongoing search for effective treatments for postoperative urinary retention. The research underscores the need for continued exploration and development of alternative approaches to address this common post-surgical complication. It's like continuing our desert journey, knowing that finding a true oasis requires perseverance and a willingness to explore new pathways.

Dr.Camel's Conclusion

This study highlights the complexity of postoperative pain management and the ongoing search for effective treatments. Just as a desert traveler must adapt to changing conditions, we must continue to explore new strategies to address the unique challenges associated with post-surgical recovery.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-01-28
Further Info :

Pubmed ID

35054148

DOI: Digital Object Identifier

PMC8780376

Related Literature

Article Analysis
・Effects of naloxegol・Side Effects of naloxegol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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