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Pharmacological interventions to diminish cognitive side effects of electroconvulsive therapy: A systematic review and meta-analysis.

Author: HofmeijerJeannette, KellnerCharles H, OudMatthijs, VerdijkJoey P A J, VerwijkEsmée, van KesselMike A, van WaardeJeroen A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and meta-analysis evaluated pharmacological interventions to reduce cognitive side effects of electroconvulsive therapy (ECT). The study found low-quality evidence supporting the efficacy of memantine and liothyronine. Other interventions, such as acetylcholine inhibitors, piracetam, and melatonin, showed potential benefit but with very low-quality evidence. Future research is needed to clarify the mechanisms underlying cognitive side effects of ECT and develop more effective interventions.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The authors conducted a systematic review and meta-analysis of pharmacological interventions to diminish cognitive side effects of ECT. METHODS: Electronic databases of Pubmed, PsycInfo, Embase and Scopus were searched from inception through 1 April, 2021, using terms for ECT (e.g. elect...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305858/

データ提供：米国国立医学図書館（NLM）

Navigating the Cognitive Desert: Finding Relief for ECT Side Effects

Electroconvulsive therapy (ECT) is a treatment for severe mental illness, like a powerful desert sandstorm that can sometimes have unintended consequences. This study explores the potential of pharmacological interventions to minimize the cognitive side effects that can occur after ECT, like seeking ways to mitigate the damage caused by a sandstorm.

A New Oasis: Memantine and Liothyronine Show Promise

The study found that memantine and liothyronine, two medications used for other conditions, showed promise in reducing cognitive side effects after ECT. This is like finding two different oases in a desert, offering alternative pathways to recovery and reducing the cognitive impact of ECT. The researchers also found that other medications, such as acetylcholine inhibitors, piracetam, and melatonin, might be beneficial for specific cognitive domains, like exploring different paths through a vast desert landscape to find the best route for each individual.

A Path to Recovery: Minimizing the Impact of ECT

This study offers valuable insights into the potential for pharmacological interventions to minimize the cognitive side effects of ECT. It’s like finding a way to reduce the impact of a sandstorm on a camel caravan, allowing for a smoother and less disruptive journey. This research could lead to the development of new and innovative approaches to manage cognitive side effects and improve the overall experience of ECT for patients.

Dr.Camel's Conclusion

This study underscores the importance of seeking solutions to mitigate the cognitive side effects of ECT. It’s like building a network of oases across a vast desert, providing support and resources for those navigating the challenges of mental illness treatment. Further research is needed to fully understand the potential of pharmacological interventions for managing cognitive side effects and to optimize their use in clinical practice.

Date :
  1. Date Completed 2022-05-02
  2. Date Revised 2022-07-31
Further Info :

Pubmed ID

35075641

DOI: Digital Object Identifier

PMC9305858

Related Literature

Article Analysis
・Effects of liothyronine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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