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Papilledema and idiopathic intracranial hypertension due to the possible potentiation of ATRA by posaconazole in a case of acute promyelocytic leukemia.

Author: AtasUnal, Aydin ErsoyMerve, IltarUtku, SalimOzan, TurkogluElif Betul, YucelOrhan Kemal

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report discusses the diagnosis and treatment process of idiopathic intracranial hypertension (IIH) emerging in a young acute promyelocytic leukemia (APL) case.
Paper Details　
Original Abstract of the Article :
Idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) is a rare side effect of all-trans retinoic acid (ATRA). IIH cases have been observed after the concomitant use of ATRA with azole group antimicrobials such as fluconazole and voriconazole. Here, we discuss about the diagnosis and trea...See full text at original site
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引用元：
https://doi.org/10.1177/10781552221076756

データ提供：米国国立医学図書館（NLM）

Papilledema and Idiopathic Intracranial Hypertension: A Potential Drug Interaction

This research explores a rare but serious side effect of [all-trans retinoic acid (ATRA)], a medication used to treat [acute promyelocytic leukemia (APL)]. The researchers present a case study of a young patient with [APL] who developed [idiopathic intracranial hypertension (IIH)] following treatment with [ATRA] and [posaconazole], an antifungal medication. They suggest that [posaconazole] may potentiate the effects of [ATRA], increasing the risk of developing [IIH].

Potential Drug Interaction: ATRA and Posaconazole

This study raises concerns about a potential [drug interaction] between [ATRA] and [posaconazole]. The researchers observe that [IIH] developed in a patient receiving both medications, suggesting that [posaconazole] may enhance the effects of [ATRA], leading to [IIH]. This finding highlights the importance of considering potential drug interactions when prescribing medications, particularly those with known side effects.

Preventing Drug Interactions: A Key Aspect of Patient Safety

This study reinforces the importance of [monitoring for potential drug interactions] to ensure patient safety. The case study highlights the need for increased awareness of the potential for [posaconazole] to potentiate the effects of [ATRA], increasing the risk of developing [IIH]. Healthcare professionals should carefully consider the potential for drug interactions when prescribing medications, especially in patients with [APL] who are receiving [ATRA] therapy.

Dr. Camel's Conclusion

This case study serves as a cautionary tale, highlighting the importance of considering potential [drug interactions] when prescribing medications. The findings suggest that [posaconazole] may potentiate the effects of [ATRA], increasing the risk of developing [IIH]. As a researcher, I am continually impressed by the complexity of drug interactions and the need for vigilance in monitoring patients for adverse effects.
Date :
  1. Date Completed 2022-08-15
  2. Date Revised 2022-08-15
Further Info :

Pubmed ID

35088649

DOI: Digital Object Identifier

10.1177/10781552221076756

SNS
PICO Info
in preparation
Languages

English

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