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<i>In Vitro</i> Activity of KBP-7072 against 536 Acinetobacter baumannii Complex Isolates Collected in China.

Author: DingLi, GuoYan, HanRenru, HuFupin, LiLi, LiuQingmei, TanXiaojuan, WuShi, YangYang, YinDandan, ZhangJay, ZhiPeiyuan, ZhuDemei, ZhuYuanju

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

KBP-7072, a novel expanded-spectrum tetracycline antibacterial agent, showed potent in vitro activity against a collection of 536 Acinetobacter baumannii (A. baumannii) clinical isolates from China. KBP-7072 was effective against all isolates, including carbapenem-resistant strains, and outperformed other tetracyclines, suggesting potential as a treatment option for infections caused by A. baumannii.
Paper Details　
Original Abstract of the Article :
Acinetobacter baumannii has emerged globally as a difficult-to-treat nosocomial pathogen and become resistant to carbapenems, resulting in limited treatment options. KBP-7072 is a novel semisynthetic aminomethylcycline, expanded spectrum tetracycline antibacterial agent with completed phase 1 clinic...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826824/

データ提供：米国国立医学図書館（NLM）

KBP-7072: A Potential Weapon Against *Acinetobacter baumannii*?

The emergence of multidrug-resistant *Acinetobacter baumannii* poses a significant threat to global health in [the field of infectious disease research]. This research evaluates the in vitro activity of KBP-7072, a novel semisynthetic aminomethylcycline antibiotic, against a large collection of *A. baumannii* isolates from China. The study found that KBP-7072 exhibited strong antibacterial activity against all isolates, including those resistant to carbapenems, tigecycline, and omadacycline. KBP-7072 outperformed other expanded-spectrum tetracyclines and showed comparable activity to colistin. These findings suggest that KBP-7072 holds promise as a potential alternative agent for treating infections caused by *A. baumannii*, even those resistant to multiple antibiotics.

A New Hope in the Fight Against Multidrug-Resistant *Acinetobacter baumannii*

The study's findings offer a ray of hope in the ongoing battle against multidrug-resistant *A. baumannii*. KBP-7072 demonstrated potent antibacterial activity against a wide range of isolates, including those resistant to commonly used antibiotics. This suggests that KBP-7072 may provide a valuable new weapon in the arsenal for treating infections caused by this challenging pathogen.

The Importance of Antibiotic Discovery: A Race Against Resistance

The emergence of antibiotic resistance is a major public health threat. This research highlights the importance of ongoing efforts to discover new antibiotics that can effectively combat resistant pathogens. Just as a desert wanderer relies on finding new water sources, we need to continue searching for novel antibiotics to stay ahead of the ever-evolving threat of drug resistance.

Dr.Camel's Conclusion

The discovery of KBP-7072, a new antibiotic with potent activity against *A. baumannii*, offers hope for a more effective treatment option. This research, like a well-placed oasis in the desert, provides a potential solution to the growing problem of drug-resistant infections.

Date :
  1. Date Completed 2022-03-07
  2. Date Revised 2022-03-07
Further Info :

Pubmed ID

35138143

DOI: Digital Object Identifier

PMC8826824

Related Literature

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・Effects of omadacycline
SNS
PICO Info
in preparation
Languages

English

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