Paper Details

  1. Home
  2. Paper Details

Adjuvant chemotherapy in the treatment of breast cancer: results of a multicentre study.

Author: BatesT D, BuchananR B, EdelstynG A, HillB T, KitchenG, MacRaeK D, MartinW M, NicolN T, OstrowskiM J, SpittleM F

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effectiveness of chemotherapy to no further treatment in 248 patients with early-stage breast cancer who had undergone surgery. Those who received chemotherapy had a significantly longer time before cancer recurrence compared to those who did not (31 months vs. 50 months). While there was a trend towards longer survival in the chemotherapy group, this difference was not statistically significant. The chemotherapy regimen used was well-tolerated, with only a small percentage of patients experiencing significant side effects. The study concludes that chemotherapy can delay cancer recurrence in patients with early-stage breast cancer and that the regimen used is suitable for both general and specialized hospitals.
Paper Details　
Original Abstract of the Article :
248 patients with locally radically treated early breast cancer (196 node-positive) were randomized post-operatively between 6 courses of a 'CMF like' chemotherapy and no further treatment. Results (with a minimum of 5 years follow-up on every patient) favour chemotherapy with a significant increase...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/3519285

データ提供：米国国立医学図書館（NLM）

Adjuvant Chemotherapy for Breast Cancer: A Multicenter Perspective

Breast cancer, a complex and often challenging disease, requires a multi-pronged approach to treatment. This study investigates the effectiveness of adjuvant chemotherapy in patients with early-stage breast cancer, where the cancer has been surgically removed. The authors conduct a multicenter trial, comparing the outcomes of patients who received adjuvant chemotherapy with those who did not. This research is a valuable contribution to the field of oncology, offering insights into the role of chemotherapy in improving long-term survival and reducing the risk of recurrence in early-stage breast cancer.

A Positive Impact: Adjuvant Chemotherapy Demonstrates Benefit

The study results demonstrate a significant benefit of adjuvant chemotherapy in patients with early-stage breast cancer, particularly those with node-positive disease. The median time to recurrence was longer for patients who received chemotherapy, suggesting a reduction in the risk of the cancer returning. While no significant impact on overall survival was observed in this study, the trend toward longer survival in the treated group warrants further investigation.

Making a Difference: Enhancing Outcomes for Breast Cancer Patients

This research highlights the importance of adjuvant chemotherapy in improving long-term outcomes for patients with early-stage breast cancer. The study provides evidence to support the current standard of care, emphasizing the value of this treatment modality in reducing the risk of recurrence and potentially improving survival. This research underscores the ongoing need for research and innovation in the field of breast cancer treatment.

Dr.Camel's Conclusion

Breast cancer is like a mirage in the desert, appearing deceptive and elusive. Adjuvant chemotherapy, like a skilled guide, can help navigate the complex terrain of this disease, increasing the chances of a favorable outcome. This research, like a beacon of hope in the desert, illuminates a path toward a brighter future for patients with breast cancer.

Date :
  1. Date Completed 1986-07-15
  2. Date Revised 2007-11-15
Further Info :

Pubmed ID

3519285

DOI: Digital Object Identifier

3519285

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.