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Molecular Landscape in Infant High-Grade Gliomas: A Single Center Experience.

Author: AntonelliManila, BarresiSabina, CacchioneAntonella, CaraiAndrea, CauloMassimo, ColafatiGiovanna Stefania, Del BaldoGiada, Di RuscioValentina, MastronuzziAngela, MieleEvelina, RossiSabrina, VinciMaria

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Molecular investigations play a fundamental role in the diagnosis and treatment of high-grade gliomas (HGG) in infants. Target therapy with NTRK inhibitors can achieve a complete remission and a very good partial response in infants with HGG.
Paper Details　
Original Abstract of the Article :
High-grade gliomas (HGG) represent about 15% of all pediatric brain tumors, with a dismal prognosis and survival rates ranging from 15 to 35%. Approximately 10-12% of pediatric HGGs (pHGG) occur in children younger than five years of age at diagnosis, specifically infants (iHGG), with an unexpected ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871476/

データ提供：米国国立医学図書館（NLM）

A New Frontier: Exploring the Molecular Landscape of Infant High-Grade Gliomas

Gliomas are like sandstorms in the brain, wreaking havoc on brain cells. But this study brings a breath of fresh air to our understanding of infant high-grade gliomas (iHGG), a particularly challenging type of brain tumor. Researchers conducted a comprehensive molecular analysis of 11 infant patients with iHGG, discovering a variety of genetic alterations, including NTRK, ROS1, MN1, and PATZ1 fusions. They also found that target therapy using larotrectinib, a NTRK inhibitor, was effective in controlling the disease in two patients, achieving complete remission and very good partial response. This study demonstrates the power of molecular investigation in identifying potential targets for personalized therapy.

Personalized Treatment: A New Oasis in the Desert of Cancer Treatment

This study shines a light on the promise of personalized medicine, especially for treating complex diseases like cancer. By analyzing the genetic makeup of each patient, we can develop more effective treatments and minimize side effects. It's like navigating through a desert of possibilities to find the perfect treatment for each patient.

The Importance of Early Diagnosis and Personalized Treatment

This study emphasizes the critical importance of early diagnosis and personalized treatment for cancer. Early detection gives us a better chance of finding effective therapies, and personalized medicine allows us to tailor treatment to each patient's unique needs. It's a reminder to always stay vigilant and seek medical attention if we suspect anything amiss.

Dr. Camel's Conclusion

This study on infant high-grade gliomas is a beacon of hope in the desert of cancer research. By delving into the molecular intricacies of these tumors, researchers are paving the way for more effective and personalized treatments. This approach holds the potential to change the landscape of cancer care, offering a brighter future for patients and their families.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-01
Further Info :

Pubmed ID

35204463

DOI: Digital Object Identifier

PMC8871476

SNS
PICO Info
in preparation
Languages

English

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