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Experience of dolutegravir-based antiretroviral treatment and risks of diabetes mellitus.

Author: EifaAberash, GutemaSelamawit, HirigoAgete Tadewos, KetemaWorku

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This report describes three HIV-infected individuals who developed type 2 diabetes after switching to a dolutegravir-based antiretroviral therapy regimen. All three patients had normal fasting blood sugar levels before switching. The study highlights the potential for dolutegravir to cause hyperglycemia and emphasizes the need for blood glucose monitoring throughout treatment initiation and follow-up, particularly for patients on dolutegravir-based regimens.
Paper Details　
Original Abstract of the Article :
HIV-infected people have started to live longer since the introduction of antiretroviral therapy, however various co-morbid illnesses have emerged. Three HIV-infected individuals, all at least 43 years old, reported with a new onset of type 2 diabetes after switching to dolutegravir-combined antiret...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874156/

データ提供：米国国立医学図書館（NLM）

Dolutegravir-Based Antiretroviral Therapy: Potential Risks of Diabetes

Dolutegravir is a powerful antiretroviral medication used to treat HIV infection. This study investigates the potential association between dolutegravir-based therapy and the development of diabetes mellitus in HIV-infected individuals. The study reports three cases of individuals who developed type 2 diabetes after switching to dolutegravir-based regimens.

Dolutegravir and Hyperglycemia: A Potential Side Effect

The study's findings suggest a possible link between dolutegravir-based therapy and the development of hyperglycemia and other diabetes-related side effects. While the cases presented in this study do not definitively prove a causal relationship, they highlight the need for caution and careful monitoring of blood glucose levels in individuals receiving dolutegravir-based therapy, particularly those with existing risk factors for diabetes.

The Importance of Vigilance and Personalized Care in HIV Treatment

This study emphasizes the importance of comprehensive monitoring and personalized care for individuals living with HIV, particularly those receiving dolutegravir-based treatment. Regular blood glucose monitoring, along with proactive management of diabetes risk factors, is crucial for ensuring optimal treatment outcomes and minimizing potential complications associated with dolutegravir therapy.

Dr. Camel's Conclusion

Just as a camel adapts to the harsh desert environment, individuals living with HIV must navigate the complexities of treatment and potential side effects. This study serves as a reminder that vigilant monitoring and personalized care are essential for ensuring the safety and effectiveness of antiretroviral therapy, including dolutegravir-based regimens.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-01
Further Info :

Pubmed ID

35223037

DOI: Digital Object Identifier

PMC8874156

Related Literature

Article Analysis
・Side Effects of dolutegravir
SNS
PICO Info
in preparation
Languages

English

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