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Are They Side Effects? Extraintestinal Symptoms Reported During Clinical Trials of Irritable Bowel Syndrome May Be More Severe at Baseline.

Author: BallouSarah, ChengVivian, ConboyLisa, HassanRafla, IturrinoJohanna, KaptchukTed J, KelleyJohn, KirschIrving, LemboAnthony, NeeJudy, RanganVikram

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Participants with irritable bowel syndrome often experience extraintestinal symptoms at baseline, and these symptoms generally improve over the course of a clinical trial.
Paper Details　
Original Abstract of the Article :
BACKGROUND & AIMS: Many of the reported adverse events in clinical trials of irritable bowel syndrome are extraintestinal symptoms, which typically are assessed by open-ended questions during the trial and not at baseline. This may lead to misattribution of some pre-existing symptoms as side effects...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35339669

データ提供：米国国立医学図書館（NLM）

The Hidden Story of Extraintestinal Symptoms in Irritable Bowel Syndrome: A Closer Look

The world of [irritable bowel syndrome (IBS)] is often filled with confusing and frustrating symptoms, and this study delves into a lesser-understood aspect of this complex condition: the prevalence and significance of extraintestinal symptoms. The authors examined data from a clinical trial, analyzing the occurrence and severity of extraintestinal symptoms in patients with IBS, both at baseline and after treatment.

Unmasking the Truth: Extraintestinal Symptoms in IBS May Be More Common Than We Think

This study reveals a surprising truth: many patients with IBS experience extraintestinal symptoms at baseline, often before the initiation of any treatment. The authors demonstrate that the frequency of these symptoms may be underestimated in clinical trials, potentially leading to misattribution of pre-existing symptoms as side effects of treatment. This research highlights the importance of a comprehensive assessment of extraintestinal symptoms in patients with IBS, both at baseline and throughout the course of treatment.

The Importance of Thorough Evaluation: A Step Towards Improved Diagnosis and Management

This study underscores the importance of conducting thorough evaluations of extraintestinal symptoms in patients with IBS. The authors advocate for a more comprehensive assessment of these symptoms, recognizing that they may contribute to the overall burden of IBS and influence treatment decisions. This research emphasizes the need for a holistic approach to managing IBS, addressing both intestinal and extraintestinal symptoms to improve patient outcomes and well-being.

Dr. Camel's Conclusion

This study sheds light on the prevalence and importance of extraintestinal symptoms in IBS, reminding us that this complex condition often extends beyond the gut. The research underscores the need for a comprehensive assessment of these symptoms to ensure accurate diagnosis, personalized treatment, and improved outcomes for patients struggling with IBS.

Date :
  1. Date Completed 2022-11-28
  2. Date Revised 2023-12-02
Further Info :

Pubmed ID

35339669

DOI: Digital Object Identifier

NIHMS1791914

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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