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Effectiveness and safety of adjunctive cenobamate for focal seizures in adults with developmental disability treated in clinical practice.

Author: ConnorGregory S, WilliamsonAmanda

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cenobamate significantly reduced focal seizure frequency in adults with developmental disabilities. 92.9% of patients continued treatment beyond 6 months, and 48.2% became seizure-free. 32.1% experienced side effects, most of which were resolved by adjusting other medications. 7.1% stopped treatment due to side effects.
Paper Details　
Original Abstract of the Article :
Effectiveness and tolerability of adjunctive cenobamate for uncontrolled focal seizures in adults living with a developmental disability are not defined. Retrospective medical record review included adults ≥18 years old living with a developmental disability, either in a group home or with parents, ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956884/

データ提供：米国国立医学図書館（NLM）

Evaluating the Effectiveness and Safety of Cenobamate for Focal Seizures in Adults with Developmental Disabilities

This research investigates the effectiveness and tolerability of adjunctive cenobamate in treating uncontrolled focal seizures in adults living with developmental disabilities. The study retrospectively reviewed medical records of 28 patients who received cenobamate in addition to at least one other antiseizure medication (ASM). The results indicate that cenobamate was associated with a substantial reduction in focal seizure frequency, with a responder rate of 100% seizure reduction in 48.2% of patients. Cenobamate was well-tolerated, with minor adverse effects reported in 32.1% of patients. The authors conclude that cenobamate is a promising and well-tolerated adjunctive therapy for uncontrolled focal seizures in adults with developmental disabilities.

Understanding the Potential Benefits of Cenobamate for Individuals with Developmental Disabilities

This research highlights the importance of exploring effective treatment options for individuals with developmental disabilities who experience uncontrolled seizures. The study's findings suggest that cenobamate may be a valuable adjunctive therapy for reducing seizure frequency in this population.

Navigating Treatment Options for Seizures in Individuals with Developmental Disabilities

This research underscores the need for safe and effective treatments for seizures in individuals with developmental disabilities. The study's findings suggest that cenobamate may be a viable option for managing seizures in this population. It's essential to consult with a physician to determine the best treatment plan based on individual patient characteristics and needs.

Dr. Camel's Conclusion

This study reminds me of the resilience of the human spirit, even in the face of challenging medical conditions. Just as a desert plant adapts to survive in harsh environments, individuals with developmental disabilities can find hope and relief through effective treatments. This research encourages us to continue striving for innovative solutions to improve the lives of those living with epilepsy.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

35345772

DOI: Digital Object Identifier

PMC8956884

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Article Analysis
・Effects of cenobamate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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