Integrated fecal microbiome-metabolome signatures reflect stress and serotonin metabolism in irritable bowel syndrome.

Author: Garcia-PerezIsabel, HolmesElaine, JonkersDaisy Mae, KasapiMelpomeni, KeszthelyiDaniel, KurilshikovAlexander, MascleeAd Am, MujagicZlatan, NicholsonJeremy K, PosmaJoram M, ScotcherJamie, Serrano-ContrerasJose Ivan, VorkLisa, WeertsZsa Zsa R M, WijmengaCisca, ZhernakovaAlexandra

Paper Details 
Original Abstract of the Article :
To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS), several modalities of biological and clinical data must be combined. We aimed to identify profiles of fecal microbiota and metabolites associated with IBS and to delineate specific phenotypes of IBS that re...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037519/

データ提供:米国国立医学図書館(NLM)

The Microbiome-Gut-Brain Axis: A Symphony of Interactions in IBS

Irritable bowel syndrome (IBS), a common gastrointestinal disorder, is a mystery waiting to be unraveled. Picture the desert as a vast ecosystem, teeming with life and intricate connections. This research explores the complex interplay between the gut microbiome, the brain, and IBS. The authors utilize a multidisciplinary approach, combining data on fecal microbiota, metabolites, and clinical characteristics. This study uncovers hidden connections, revealing the intricate dance between the gut and the brain in IBS.

Decoding the Desert: Microbiome-Metabolome Signatures

The researchers identified distinct fecal microbiome and metabolome profiles associated with IBS. Imagine a desert landscape, each dune representing a different microbial community. This study reveals a potential link between these microbial communities and the development of IBS. The authors demonstrate the power of integrating different data types, offering new insights into the pathogenesis of this complex disorder.

Navigating the Gut-Brain Desert: A Path to Personalized Therapies

This research suggests that microbiome-metabolome profiles may hold the key to developing personalized therapies for IBS. Imagine a map of the desert, with unique pathways leading to different oases of well-being. This study paves the way for a more precise understanding of IBS and the development of targeted treatments tailored to individual patients.

Dr. Camel's Conclusion

The gut microbiome plays a crucial role in the development of IBS. This research sheds light on the intricate connections between the gut, the brain, and the microbial communities inhabiting our intestines. The desert of IBS is a challenging landscape, but with increased understanding of these connections, we can find new pathways towards effective treatments.

Date :
  1. Date Completed 2022-04-25
  2. Date Revised 2023-02-08
Further Info :

Pubmed ID

35446234

DOI: Digital Object Identifier

PMC9037519

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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