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Integrated fecal microbiome-metabolome signatures reflect stress and serotonin metabolism in irritable bowel syndrome.
Author: Garcia-PerezIsabel, HolmesElaine, JonkersDaisy Mae, KasapiMelpomeni, KeszthelyiDaniel, KurilshikovAlexander, MascleeAd Am, MujagicZlatan, NicholsonJeremy K, PosmaJoram M, ScotcherJamie, Serrano-ContrerasJose Ivan, VorkLisa, WeertsZsa Zsa R M, WijmengaCisca, ZhernakovaAlexandra
Original Abstract of the Article :
To gain insight into the complex microbiome-gut-brain axis in irritable bowel syndrome (IBS), several modalities of biological and clinical data must be combined. We aimed to identify profiles of fecal microbiota and metabolites associated with IBS and to delineate specific phenotypes of IBS that re...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037519/
データ提供:米国国立医学図書館(NLM)
The Microbiome-Gut-Brain Axis: A Symphony of Interactions in IBS
Irritable bowel syndrome (IBS), a common gastrointestinal disorder, is a mystery waiting to be unraveled. Picture the desert as a vast ecosystem, teeming with life and intricate connections. This research explores the complex interplay between the gut microbiome, the brain, and IBS. The authors utilize a multidisciplinary approach, combining data on fecal microbiota, metabolites, and clinical characteristics. This study uncovers hidden connections, revealing the intricate dance between the gut and the brain in IBS.
Decoding the Desert: Microbiome-Metabolome Signatures
The researchers identified distinct fecal microbiome and metabolome profiles associated with IBS. Imagine a desert landscape, each dune representing a different microbial community. This study reveals a potential link between these microbial communities and the development of IBS. The authors demonstrate the power of integrating different data types, offering new insights into the pathogenesis of this complex disorder.
Navigating the Gut-Brain Desert: A Path to Personalized Therapies
This research suggests that microbiome-metabolome profiles may hold the key to developing personalized therapies for IBS. Imagine a map of the desert, with unique pathways leading to different oases of well-being. This study paves the way for a more precise understanding of IBS and the development of targeted treatments tailored to individual patients.
Dr. Camel's Conclusion
The gut microbiome plays a crucial role in the development of IBS. This research sheds light on the intricate connections between the gut, the brain, and the microbial communities inhabiting our intestines. The desert of IBS is a challenging landscape, but with increased understanding of these connections, we can find new pathways towards effective treatments.
Date :
- Date Completed 2022-04-25
- Date Revised 2023-02-08
Further Info :
Related Literature
English
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