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The Dose and Duration-dependent Association between Melatonin Treatment and Overall Cognition in Alzheimer's Dementia: A Network Meta- Analysis of Randomized Placebo-Controlled Trials.

Author: CarvalhoAndre F, ChenTien-Yu, ChenYen-Wen, ChengYu-Shian, HsuChih-Wei, LiDian-Jeng, LiangChih-Sung, LinPao-Yen, MatsuokaYutaka J, ShiueYow-Ling, StubbsBrendon, SuKuan-Pin, SunCheuk-Kwan, TsengPing-Tao, TuYu-Kang, WuYi-Cheng, YangChun-Pai, YehPin-Yang, ZengBing-Yan

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This study reviewed the potential benefits of exogenous melatonin for cognition in Alzheimer's dementia (AD). The study found divergent results across trials and emphasized the need for further research to determine the efficacy of melatonin for AD.
Paper Details　
Original Abstract of the Article :
While Alzheimer's dementia (AD) has a prevalence as high as 3-32% and is associated with cognitive dysfunction and the risk of institutionalization, no efficacious and acceptable treatments can modify the course of cognitive decline in AD. Potential benefits of exogenous melatonin for cognition have...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886806/

データ提供：米国国立医学図書館（NLM）

Melatonin: A Potential Ally in the Fight Against Alzheimer's Dementia

Alzheimer's dementia (AD) is a devastating neurodegenerative disease, much like a relentless desert storm that erodes cognitive function. This network meta-analysis investigates the potential benefits of melatonin treatment for cognition in individuals with AD. The authors review a comprehensive dataset of randomized placebo-controlled trials, exploring the dose- and duration-dependent effects of melatonin on overall cognitive function.

Melatonin: A Promising Avenue for Cognitive Enhancement

This research, much like a desert traveler seeking a hidden oasis of knowledge, explores the potential of melatonin to mitigate the cognitive decline associated with AD. While the findings suggest a possible dose- and duration-dependent association between melatonin treatment and overall cognition, further research is needed to confirm these preliminary observations. This research paves the way for future investigations into the role of melatonin in managing AD and enhancing cognitive function.

Navigating the Desert of Alzheimer's Disease

This research, like a beacon of hope in the vast desert of Alzheimer's disease, offers potential avenues for improving cognitive function in individuals with AD. While more research is needed to fully understand the role of melatonin in treating this complex disease, these findings highlight the importance of exploring innovative therapeutic approaches to address this growing global health concern. As we continue to unravel the mysteries of AD, research like this provides valuable insights into potential treatment strategies.

Dr.Camel's Conclusion

This research, much like a camel caravan carrying a precious cargo of hope, delves into the potential of melatonin to improve cognitive function in individuals with Alzheimer's disease, offering a promising avenue for future research and potential treatment strategies.
Date :
  1. Date Completed 2022-09-16
  2. Date Revised 2023-03-01
Further Info :

Pubmed ID

35450525

DOI: Digital Object Identifier

PMC9886806

Related Literature

Article Analysis
・Effective treatment of dementia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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