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Clearance of Hepatitis B e Antigen in Untreated Chronic Hepatitis B Virus Infection: A Systematic Review and Meta-analysis.

Author: BoydAnders, CoffiePatrick A, FreedbergKenneth A, HyleEmily P, KimArthur Y, KouaméMenan Gérard, LiuAnne F, MoharebAmir M

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This systematic review and meta-analysis evaluated the rate of hepatitis B e antigen (HBeAg) loss in untreated chronic hepatitis B virus (HBV) infection. 26 cohort studies were included. The pooled rate of HBeAg loss was 6.46/100 person-years, with variations by region and age group.
Paper Details　
Original Abstract of the Article :
BACKGROUND: In people with hepatitis B virus (HBV) infection, persistence of hepatitis B e antigen (HBeAg) is associated with clinical progression and need for treatment. HBeAg loss represents partial immune control and is a critical event in the natural history of chronic HBV. METHODS: We conducte...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205627/

データ提供：米国国立医学図書館（NLM）

Hepatitis B e Antigen Clearance: A Natural Process with Regional Variations

This study explores the natural history of chronic hepatitis B virus (HBV) infection, specifically focusing on the spontaneous clearance of hepatitis B e antigen (HBeAg). The researchers conducted a systematic review and meta-analysis of cohort studies that reported HBeAg loss in untreated individuals with chronic HBV. The study found that spontaneous HBeAg loss occurred at a rate of 6.46 per 100 person-years, with significant variations by region and age group. These findings provide valuable insights into the natural course of HBV infection and highlight the importance of considering regional differences in treatment strategies.

The Natural Course of HBV Infection: Insights from HBeAg Clearance

This study provides valuable insights into the natural course of chronic HBV infection. The researchers found that HBeAg loss, representing partial immune control, occurs at a rate of 6.46 per 100 person-years, suggesting that some individuals may experience spontaneous improvement in their condition. However, the study also highlights the importance of considering regional variations in HBeAg loss rates, suggesting that different treatment strategies may be required depending on geographical location.

Implications for HBV Management and Future Research

This research has significant implications for the management of chronic HBV infection. The study's findings provide valuable information regarding the natural course of the disease and highlight the potential for spontaneous HBeAg loss in some individuals. However, the study also emphasizes the need for personalized treatment strategies, considering regional variations in HBeAg loss rates and other factors. Further research is needed to identify factors that influence HBeAg loss and to develop more effective treatments for individuals with chronic HBV infection.

Dr.Camel's Conclusion

Like a desert landscape that undergoes transformative changes with the passing seasons, the course of chronic HBV infection can vary significantly. This study provides valuable insights into the natural history of the disease, highlighting the importance of considering regional differences and the potential for spontaneous improvement in some individuals. This research serves as a reminder that understanding the nuances of disease progression is crucial for developing effective treatment strategies and improving patient outcomes.

Date :
  1. Date Completed 2022-11-14
  2. Date Revised 2023-05-26
Further Info :

Pubmed ID

35511194

DOI: Digital Object Identifier

PMC10205627

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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