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Serum Concentrations of Losartan Metabolites Correlate With Improved Physical Function in a Pilot Study of Prefrail Older Adults.
Author: AbadirPeter M, AndersNicole M, BicharaMarcela-Dávalos, ButaBrian, CareyRobert M, FerrucciLuigi, GabrawyMariann M, KhadeerMohammed, KwakMin-Ji, LeAnne, LeeJessica L, MaLina, MarxRuth, MoaddelRuin, NidadavoluLolita, RudekMichelle A, SiragyHelmy M, TianJing, WalstonJeremy D, WestbrookReyhan, WuYuqiong, XueQian-Li, YangHuanle, YenokyanGayane, ZhangCissy, de CaboRafael
Original Abstract of the Article :
Losartan is an oral antihypertensive agent that is rapidly metabolized to EXP3174 (angiotensin-subtype-1-receptor blocker) and EXP3179 (peroxisome proliferator-activated receptor gamma [PPARγ] agonist), which was shown in animal studies to reduce inflammation, enhance mitochondrial energetics, and i...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799219/
データ提供:米国国立医学図書館(NLM)
Losartan Metabolites and Improved Physical Function in Older Adults
Navigating the challenges of aging, we often seek ways to maintain physical function and vitality. This study explores the potential of losartan, an antihypertensive medication, in prefrail older adults. While losartan is known for its blood pressure-lowering effects, researchers discovered that its metabolites, EXP3174 and EXP3179, may have additional benefits. Animal studies suggest these metabolites could reduce inflammation, enhance energy production, and support muscle repair.
Losartan Metabolites Show Promise in Improving Physical Function
The study found that losartan treatment was associated with a lower risk of frailty and improvements in knee strength. Importantly, these benefits were linked to the levels of EXP3174 and EXP3179 in the blood, suggesting a direct relationship between these metabolites and improved physical function.
Implications for Frailty and Healthy Aging
This research highlights the potential of losartan and its metabolites in supporting healthy aging. It's important to note that this was a pilot study with a small sample size, so further research is needed to confirm these findings. However, it provides valuable insights into the potential of losartan beyond blood pressure management.
Dr. Camel's Conclusion
This study reminds us that even in the desert of aging, there may be hidden oases of potential. Losartan and its metabolites could hold the key to maintaining physical function and combating frailty. It's a promising glimpse into the future of aging and a reminder that we must constantly explore new avenues for maintaining health and vitality.
Date :
- Date Completed 2023-01-02
- Date Revised 2023-08-25
Further Info :
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