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Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women.

Author: AndasorovaReni, BochevaValeria, BoyanovaNatalia, BroshtilovaValentina, DakovaTsvetelina, DimitrovaJenya, GinchevaVeronika, GospodinovaKlimentina, GotsevaSvetlana, JelevaDenitsa, KatevaMarieta, KazandjievaJana, KirchevaKamelia, MarinaSonya, MilaniMassimo, MilanovaMaya, MitovaZlatka, SankevaMarina, TodevaViolina, TsankovNikolay, VasilevaIrida, YankovDaniel, YankovaRumyana, ZlatevaPetya, ZografovaEmiliya

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This randomized clinical trial evaluated the efficacy and tolerability of a cream containing retinoids and Iris Florentina root extract, with or without a prebiotic and anti-inflammatory food supplement, for treating adult female acne (AFA). Both regimens were effective in reducing acne lesions, but the combination therapy showed additional benefit in reducing inflammatory lesions and improving severity scores.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Adult female acne (AFA) nowadays is a very common skin condition affecting mainly women aged between 25 and 40. The treatment of AFA could be challenging. STUDY AIM: We evaluate and compare the efficacy and tolerability of a cream formulation containing two retinoid molecules (hydroxypi...See full text at original site
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引用元：
https://doi.org/10.1111/jocd.15074

データ提供：米国国立医学図書館（NLM）

A New Approach to Adult Female Acne: Combining Topical Retinoids with a Prebiotic Food Supplement

This study explores innovative approaches to tackling the common skin condition of [adult female acne (AFA)]. The researchers evaluated the efficacy and tolerability of a [topical cream] containing a combination of [retinoid molecules] and [Iris Florentina root extract], both alone and in combination with a [prebiotic food supplement]. The study involved a [randomized, assessor-blinded, parallel-group, multicenter trial] with [184 women] participating.

A Promising Combination for Reducing Acne Lesions

The findings revealed a significant reduction in both inflammatory and non-inflammatory acne lesions in both treatment groups, indicating the effectiveness of both regimens. However, the combination of topical cream and prebiotic food supplement demonstrated a greater reduction in inflammatory lesions and improved overall acne severity scores, suggesting a potential synergistic effect. Both treatment regimens were well-tolerated, with no significant adverse events reported.

Unlocking the Potential of Topical Retinoids and Prebiotics for Acne

This study provides valuable insights into the potential benefits of combining topical retinoids with a prebiotic food supplement for managing adult female acne. The findings suggest that this approach could offer a more comprehensive and effective treatment strategy compared to using topical retinoids alone. Further research is warranted to explore the long-term efficacy and potential mechanisms underlying this promising approach.

Dr.Camel's Conclusion

This study offers a glimpse into the potential of combining topical retinoids with prebiotics to effectively address adult female acne. It's like finding a hidden oasis in the desert – a natural solution that could offer relief and improve skin health. This research encourages further investigation into this promising approach, potentially opening up new avenues for managing acne and other skin conditions.

Date :
  1. Date Completed 2022-12-27
  2. Date Revised 2023-01-03
Further Info :

Pubmed ID

35545875

DOI: Digital Object Identifier

10.1111/jocd.15074

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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