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Determination of the optimal dosage regimen of captopril + hydrochlorothiazide in the treatment of moderate arterial hypertension.

Author: ChildsM, LancrenonS, LanguillatJ M, MatteiA, MilletB, SchwebigA, StephanA, SteruD

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study evaluated the effectiveness of different doses of captopril + hydrochlorothiazide for treating mild hypertension. The combination effectively lowered blood pressure, with the optimal dose being 50mg of captopril plus 25mg of hydrochlorothiazide.
Paper Details　
Original Abstract of the Article :
A multicentre controlled trial was carried out to determine the optimal dosage of a 2/1 combination of captopril plus hydrochlorothiazide (HCTZ) in mild hypertension at three doses against placebo in a 6 week double-blind trial. The number of patients was 111:27 received placebo; 26 were treated wit...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2125.1987.tb03123.x

データ提供：米国国立医学図書館（NLM）

Optimizing Captopril + Hydrochlorothiazide Dosage for Mild Hypertension

The field of [Hypertension Management] seeks to optimize [Medication Dosage] for effective blood pressure control. This multicentre controlled trial aimed to determine the optimal dosage regimen of a captopril plus hydrochlorothiazide (HCTZ) combination for mild hypertension. The study involved 111 patients who were randomly assigned to receive either placebo or one of three doses of captopril + HCTZ (25/12.5, 50/25, or 100/50) for six weeks. The results reveal that all active treatments resulted in a significant fall in blood pressure, with the percentage of patients achieving normalization or good response increasing as a function of the dose. The study concludes that a 50/25 dosage appeared to be the optimal dose for controlling mild hypertension, balancing efficacy with tolerability.

Dosage Optimization: Balancing Efficacy and Tolerability

This study provides valuable insights into the optimal dosage regimen of a captopril + HCTZ combination for mild hypertension. The research demonstrates that a 50/25 dosage appears to be most effective in achieving blood pressure control while minimizing side effects.

Hypertension Management: Tailoring Treatment to Individual Needs

This research highlights the importance of considering individual factors when determining medication dosages for hypertension management. The study's findings suggest that the optimal dosage regimen may vary based on factors such as the severity of hypertension, individual patient characteristics, and tolerability of the medication.

Dr.Camel's Conclusion

Just as a camel adapts its pace to the changing desert landscape, healthcare providers must carefully tailor medication dosages to the unique needs of each patient. This research provides valuable guidance for optimizing captopril + HCTZ dosage for mild hypertension, ensuring effective blood pressure control while minimizing potential side effects.

Date :
  1. Date Completed 1987-06-26
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

3555584

DOI: Digital Object Identifier

10.1111/j.1365-2125.1987.tb03123.x

SNS
PICO Info
in preparation
Languages

English

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