Side Effects of captopril and hydrochlorothiazide: A Synthesis of Findings from 6 Studies

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Original Abstract of the Article

Main Research Findings

Multiple studies have shown that the combination of captopril and hydrochlorothiazide is effective in treating mild to moderate hypertension. 5 , 2 , 4 , 1 , 3 , 6 These studies demonstrate that the combination effectively lowers blood pressure and is safe for use in various age groups, including the elderly. 1

Reasons for Side Effects

Side effects of the combination of captopril and hydrochlorothiazide are mainly attributed to captopril. Captopril lowers blood pressure by inhibiting angiotensin-converting enzyme (ACE) but can cause vasodilation and rapid blood pressure drops due to this ACE-inhibiting action. Additionally, captopril may affect kidney function. Hydrochlorothiazide is a diuretic that lowers blood pressure by eliminating water and salt from the body. Its diuretic action can lead to dehydration and electrolyte imbalances.

Common Side Effects

Dizziness

Dizziness has been reported as a side effect of the combination of captopril and hydrochlorothiazide. 2 This could be caused by a rapid drop in blood pressure. If you experience dizziness, rest and observe your condition. Consult a doctor if symptoms persist.

Headache

Headache has been reported as a side effect of the combination of captopril and hydrochlorothiazide. 3 This could be caused by a rapid drop in blood pressure. Consult a doctor if headaches are severe.

Digestive Problems

Digestive problems have been reported as a side effect of the combination of captopril and hydrochlorothiazide. 3 This could be caused by captopril's impact on the gastrointestinal system. Consult a doctor if digestive problems are severe.

Rash

Rash has been reported as a side effect of the combination of captopril and hydrochlorothiazide. 6 This could be an allergic reaction to captopril. Consult a doctor if a rash appears.

Cough

Cough has been reported as a side effect of the combination of captopril and hydrochlorothiazide. 6 This could be caused by captopril's impact on the lungs. Consult a doctor if coughing is severe.

Low Blood Pressure

Low blood pressure has been reported as a side effect of the combination of captopril and hydrochlorothiazide. 5 This could be caused by captopril's vasodilatory effect. Consult a doctor if blood pressure is too low.

Dehydration

Dehydration has been reported as a side effect of the combination of captopril and hydrochlorothiazide. 3 This could be caused by hydrochlorothiazide's diuretic effect. Consult a doctor if dehydration is severe.

Electrolyte Imbalance

Electrolyte imbalance has been reported as a side effect of the combination of captopril and hydrochlorothiazide. 3 This could be caused by hydrochlorothiazide's diuretic effect. Consult a doctor if electrolyte imbalance is severe.

Side Effect Management

Dizziness

Consult a doctor if dizziness is severe. The doctor may adjust the amount of blood pressure medication or suggest alternative treatments. To reduce the likelihood of dizziness, stand up and sit down slowly.

Headache

Consult a doctor if headaches are severe. The doctor may adjust the amount of blood pressure medication or suggest alternative treatments. Taking headache medication can also be helpful.

Digestive Problems

Consult a doctor if digestive problems are severe. The doctor may suggest changing captopril to another medication or prescribing medication to alleviate digestive problems. Pay attention to your diet and eat easily digestible foods.

Rash

Consult a doctor if a rash appears. The doctor may suggest switching to another medication or prescribing medication to reduce the allergic reaction.

Cough

Consult a doctor if coughing is severe. The doctor may suggest switching to another medication or prescribing cough suppressants.

Low Blood Pressure

Consult a doctor if blood pressure is too low. The doctor may adjust the amount of blood pressure medication or suggest alternative treatments.

Dehydration

Consult a doctor if dehydration is severe. The doctor will assess the need for rehydration and take appropriate action. To prevent dehydration, stay adequately hydrated by drinking plenty of fluids.

Electrolyte Imbalance

Consult a doctor if electrolyte imbalance is severe. The doctor will provide treatment to restore electrolyte balance. To prevent electrolyte imbalances, eat a balanced diet.

Study Comparisons

Commonalities

Multiple studies have shown that the combination of captopril and hydrochlorothiazide is effective in treating mild to moderate hypertension. 5 , 2 , 4 , 1 , 3 , 6 These studies demonstrate that the combination effectively lowers blood pressure and is safe for use in various age groups, including the elderly. 1

Differences

The optimal dosage of the combination of captopril and hydrochlorothiazide varies across studies. 5 , 2 Also, the frequency and types of side effects can differ between studies.

Cautions for Real-Life Applications

Captopril and hydrochlorothiazide should be taken under the guidance of a doctor. Avoid self-discontinuation of medication or dose adjustments.

Limitations of Current Research

Further research is needed to assess the long-term safety of the combination of captopril and hydrochlorothiazide. Moreover, further research is required to understand how this combination affects patients with specific diseases or conditions.

Future Research Directions

Larger-scale clinical trials are necessary to assess the long-term safety and effectiveness of the combination of captopril and hydrochlorothiazide. Additionally, more research is needed to understand how this combination affects patients with specific diseases or conditions.

Conclusion

The combination of captopril and hydrochlorothiazide is an effective and safe treatment option for mild to moderate hypertension. However, this combination can cause side effects such as dizziness, headache, digestive problems, rash, cough, low blood pressure, dehydration, and electrolyte imbalance. When taking the combination of captopril and hydrochlorothiazide, follow your doctor's instructions and be aware of potential side effects.

Literature analysis of 6 papers
Positive Content
6
Neutral Content
0
Negative Content
0
Article Type
3
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6
1.

Captopril/hydrochlorothiazide combination in elderly patients with mild-moderate hypertension. A double-blind, randomized, placebo-controlled study.

Author: CreissonC, BaulacL, LenfantB

Hypertension treatment

A fixed combination of captopril and hydrochlorothiazide was effective and safe in treating mild to moderate hypertension in elderly patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Captopril and hydrochlorothiazide in the fixed combination multicenter trial.

Author: LederleR M

Fewer side effects
Reduced blood pressure

Low-dose captopril combined with hydrochlorothiazide is effective in lowering blood pressure and reducing side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

[Efficacy and tolerability of captopril-hydrochlorothiazide vs amiloride-hydrochlorothiazide combination in mild to moderate arterial hypertension].

Author: MammarellaA, PaolettiV, BarlattaniM, LeoneG, FilippelloC P, MarianiA R

Blood pressure reduction
Blood glucose increase

Both captopril-hydrochlorothiazide and amiloride-hydrochlorothiazide combinations effectively reduced blood pressure in patients with essential hypertension, with captopril-hydrochlorothiazide showing greater efficacy in reducing diastolic values.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

4.

[Efficacy and tolerability of the captopril and hydrochlorothiazide combination in the treatment of mild to moderate hypertension. Multicenter study].

Author: Velasco-CornejoI F, MartinL C, FrancoR J

Captopril/hydrochlorothiazide for hypertension
Cough

Captopril 50 mg + hydrochlorothiazide 25 mg daily was effective and safe in treating mild to moderate hypertension. A favorable response was observed in 82% of patients, with cough being the main adverse event.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : Portuguese

5.

Determination of the optimal dosage regimen of captopril + hydrochlorothiazide in the treatment of moderate arterial hypertension.

Author: SteruD, ChildsM, LancrenonS, LanguillatJ M, MatteiA, MilletB, SchwebigA, StephanA

Decrease blood pressure
Side effects

This study evaluated the effectiveness of different doses of captopril + hydrochlorothiazide for treating mild hypertension. The combination effectively lowered blood pressure, with the optimal dose being 50mg of captopril plus 25mg of hydrochlorothiazide.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

[Fixed drug combination of ACE inhibitor plus diuretic. Results of an open multicenter study for the treatment of hypertension].

Author: LederleR M

Effective for mild-to-moderate hypertension
Lowers blood pressure
Side effects

A fixed combination of captopril and hydrochlorothiazide (Capozide) was effective in lowering blood pressure in patients with mild-to-moderate hypertension. In a study of 34,976 patients, 87.2% achieved a significant reduction in blood pressure after 8 weeks of treatment. The most common side effect was mild and occurred in 7.4% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : German

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