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The addition of androgen deprivation therapy and pelvic lymph node treatment to prostate bed salvage radiotherapy (NRG Oncology/RTOG 0534 SPPORT): an international, multicentre, randomised phase 3 trial.
Author: AllenAaron M, AngyalfiSteve J, BaloghAlexander G, BeaucheminMarie-Claude, BrunerDeborah W, FariaSergio L, FengFelix, GomellaLeonard G, KarrisonTheodore G, LeeR Jeffrey, LowDaniel A, LukkaHimanshu, MartinAndre-Guy, MichalskiJeff M, MonittoDrew C, PollackAlan, RodriguesGeorge B, SandlerHoward M, SartorOliver, SeawardSamantha A, SeiferheldWendy, WefelJeffrey S
Original Abstract of the Article :
In men with a detectable prostate-specific antigen (PSA) level after prostatectomy for prostate cancer, salvage prostate bed radiotherapy (PBRT) results in about 70% of patients being free of progression at 5 years. A three-group randomised trial was designed to determine whether incremental gains i...See full text at original site
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引用元:
https://doi.org/10.1016/S0140-6736(21)01790-6
データ提供:米国国立医学図書館(NLM)
The Search for Optimal Treatments for Prostate Cancer: A Camel's Perspective
The desert of prostate cancer research is constantly evolving, with new therapies and strategies emerging to combat this disease. This research focuses on men who have undergone prostatectomy, a surgical procedure to remove the prostate, but still face the threat of recurrent cancer. The authors seek to determine whether adding additional treatments, such as androgen deprivation therapy (ADT) or pelvic lymph node radiotherapy (PLNRT), to salvage prostate bed radiotherapy (PBRT) can improve outcomes.
A Multifaceted Approach to Combating Prostate Cancer
This study investigates the potential of combining different treatments to enhance the effectiveness of salvage PBRT. The authors found that adding either ADT or both ADT and PLNRT to PBRT did not significantly improve outcomes compared to PBRT alone. These findings, like a desert landscape that reveals both fertile oases and barren stretches, suggest that a single, dominant strategy may not be the best approach. A tailored treatment plan based on individual patient factors may be more effective.
Navigating the Complexities of Prostate Cancer Treatment
This research highlights the complexities of prostate cancer treatment and the ongoing quest for optimal approaches. The study's findings suggest that combining different therapies may not always lead to better outcomes. This emphasizes the need for personalized treatment plans and careful consideration of individual patient factors. Just as a camel adapts its travel route to the unique challenges of the desert, healthcare professionals must tailor treatment strategies to the specific needs of each patient.
Dr. Camel's Conclusion
This study provides valuable insights into the use of adjuvant therapies in prostate cancer. The authors' findings suggest that a multidisciplinary approach, carefully tailored to individual patient characteristics, may be the most effective strategy for managing this complex disease. Continued research is needed to explore the full potential of these treatment options and to develop more effective and personalized approaches to care.
Date :
- Date Completed 2022-05-19
- Date Revised 2023-04-21
Further Info :
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