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A Systematic Review of Nonclinical Studies on the Effect of Curcumin in Chemotherapy- induced Cardiotoxicity.

Author: AbdollahiMohammad, ArmandehMaryam, BameriBehnaz, ForoumadiRoham, HeidariShima, SamadiMahedeh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review evaluated the potential cardioprotective effects of curcumin against chemotherapy-induced cardiotoxicity. 25 relevant articles were analyzed. Curcumin at nontoxic doses showed potential for protecting cardiac cells through antioxidant, anti-inflammatory, and cell death modulation effects. However, contradictory findings warrant further research to determine its safety and efficacy.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Various anticancer drugs are effective therapeutic agents for cancer treatment; however, they cause severe toxicity in body organs. Cardiotoxicity is one of the most critical side effects of these drugs. Based on various findings, turmeric extract has positive effects on cardiac cells. ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.2174/1381612828666220513125312

データ提供：米国国立医学図書館（NLM）

Curcumin: A Potential Protector Against Chemotherapy-Induced Cardiotoxicity

This systematic review explores the potential cardioprotective effects of curcumin, a natural compound found in turmeric, against chemotherapy-induced cardiotoxicity. The researchers analyzed a comprehensive set of nonclinical studies investigating the impact of curcumin on heart function in the context of chemotherapy.

Curcumin: A Potential Shield for the Heart

The review reveals that curcumin, when administered at nontoxic doses, can potentially protect cardiac cells from the damaging effects of chemotherapy. The studies suggest that curcumin's protective effects may be mediated through its antioxidant, anti-inflammatory, and cell death-regulating properties.

Navigating the Potential of Natural Compounds

This review highlights the potential of natural compounds like curcumin to mitigate the side effects of chemotherapy. The research offers a promising avenue for developing safer and more effective cancer treatments. However, the review also acknowledges that further research is needed to confirm the safety and efficacy of curcumin in this context. As Dr. Camel, I am always intrigued by the potential of natural remedies to address complex health challenges. This review provides a compelling case for further research into the cardioprotective effects of curcumin.

Dr.Camel's Conclusion

This systematic review provides encouraging evidence for the potential of curcumin to protect against chemotherapy-induced cardiotoxicity. Further research is needed to confirm these findings and evaluate the safety and efficacy of curcumin as a cardioprotective agent in cancer therapy.

Date :
  1. Date Completed 2022-08-30
  2. Date Revised 2022-09-22
Further Info :

Pubmed ID

35570565

DOI: Digital Object Identifier

10.2174/1381612828666220513125312

Related Literature

Article Analysis
・Side Effects of turmeric
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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