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Effects of estradiol on bone in men undergoing androgen deprivation therapy: a randomized placebo-controlled trial.

Author: CheungAda S, EbelingPeter R, Ghasem-ZadehAli, GrossmannMathis, HandelsmanDavid J, HoermannRudolf, RussellNicholas, Shore-LorentiCat, ZajacJeffrey D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Estradiol (E2) treatment increased some measures of bone density and strength in men and reduced bone remodeling, even in the absence of endogenous testosterone.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: In men, many effects of testosterone (T) on the skeleton are thought to be mediated by estradiol (E2), but trial evidence is largely lacking. This study aimed to determine the effects of E2 on bone health in men in the absence of endogenous T. DESIGN: This study is a 6-month randomized, ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35666800

データ提供：米国国立医学図書館（NLM）

Estradiol: A Hidden Oasis in the Desert of Androgen Deprivation

[Androgen deprivation therapy (ADT)] is a common treatment for [prostate cancer], but it can have significant side effects. This study, like a desert explorer seeking a way to mitigate the harshness of the environment, investigated the effects of [estradiol (E2)] on bone health in men undergoing ADT. Researchers compared the effects of E2 to placebo in men receiving ADT, looking for signs of bone loss.

Estradiol: Preserving Bone Strength in the Desert of ADT

This research, like a sturdy camel providing support in a harsh landscape, reveals the potential of E2 to protect against bone loss in men undergoing ADT. The researchers found that E2 treatment was [associated with increased bone density and strength] in men receiving ADT. This finding, like a refreshing spring in the desert, suggests that E2 could be a valuable tool for managing the bone loss associated with ADT.

Bone Health and Prostate Cancer: Navigating the Desert of Treatment

This study, like a reminder to wear protective gear in the desert, underscores the importance of maintaining bone health in men undergoing ADT. The researchers found that E2 treatment could help to protect bone density and strength, reducing the risk of fractures. Navigating the desert of prostate cancer treatment requires a comprehensive approach, addressing both the cancer and its potential side effects.

Dr.Camel's Conclusion

This research is like a map leading us to a more stable path through the desert of ADT. Estradiol, like a hidden oasis, could offer valuable protection against bone loss, allowing men to navigate the journey of prostate cancer treatment with greater strength and resilience.

Date :
  1. Date Completed 2022-07-29
  2. Date Revised 2022-07-29
Further Info :

Pubmed ID

35666800

DOI: Digital Object Identifier

EJE-22-0227

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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