Paper Details

  1. Home
  2. Paper Details

Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress.

Author: Al-GareebAli I, Al-KuraishyHayder M, AlorabiMohammed, BatihaGaber El-Saber, CavaluSimona, El-KademAya H, Mostafa-HedeabGomaa, NegmWalaa A, SaadHebatallah M, YoussefAmal

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the renoprotective effects of pentoxifylline (PTX), berberine (BER), and their combination against diclofenac-induced acute nephrotoxicity in rats. PTX, BER, and their combination significantly attenuated biochemical and histopathological changes associated with nephrotoxicity, suggesting their potential for preventing or treating this condition.
Paper Details　
Original Abstract of the Article :
Nephrotoxicity (NT) is a renal-specific situation caused by different toxins and drugs like non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs like diclofenac (DCF) lead to glomerular dysfunction. Pentoxifylline (PTX) and berberine (BER) have antioxidant and anti-inflammatory properties. Thus, t...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.biopha.2022.113225

データ提供：米国国立医学図書館（NLM）

Fighting Nephrotoxicity: A Combined Approach to Protect the Kidneys

Diclofenac, a commonly used nonsteroidal anti-inflammatory drug (NSAID), can sometimes cause nephrotoxicity, damaging the kidneys. This study investigated the protective effects of pentoxifylline (PTX) and berberine (BER), known for their antioxidant and anti-inflammatory properties, against diclofenac-induced nephrotoxicity. The researchers studied the effects of PTX, BER, and their combination in a rat model of diclofenac-induced acute nephrotoxicity.

Combined Therapy Offers Superior Protection

The study found that both PTX and BER significantly reduced the biochemical and histopathological changes associated with diclofenac-induced nephrotoxicity. However, the combination of PTX and BER demonstrated a more pronounced protective effect, highlighting the synergistic benefits of this combined therapy. The study suggests that this combination might be a valuable strategy for mitigating the nephrotoxic effects of diclofenac, protecting the kidneys from damage.

Protecting Kidney Health: A Combined Approach

This research suggests that a combined approach using PTX and BER could be an effective way to protect the kidneys from diclofenac-induced nephrotoxicity. Like a traveler crossing a scorching desert, it's essential to take steps to protect ourselves from the harsh effects of certain medications. By combining these two protective agents, we might be able to create a shield against potential kidney damage.

Dr. Camel's Conclusion

This study highlights the potential of a combined approach using PTX and BER to protect the kidneys from the damaging effects of diclofenac. It's like finding a hidden oasis of protection in the desert, providing a shield against the harsh effects of certain medications.

Date :
  1. Date Completed 2022-06-22
  2. Date Revised 2022-06-22
Further Info :

Pubmed ID

35671584

DOI: Digital Object Identifier

10.1016/j.biopha.2022.113225

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.