Rates of Response to Atogepant for Migraine Prophylaxis Among Adults: A Secondary Analysis of a Randomized Clinical Trial.

Author: BlumenfeldAndrew M, DabruzzoBrett, DodickDavid W, FinneganMichelle, LiYe, LiptonRichard B, LuKaifeng, McAllisterPeter, MiceliRosa, Pozo-RosichPatricia, SevertLawrence, TrugmanJoel M

Paper Details 
Original Abstract of the Article :
IMPORTANCE: Some patients with migraine, particularly those in primary care, require effective, well-tolerated, migraine-specific oral preventive treatments. OBJECTIVE: To examine the efficacy of atogepant, an oral, small-molecule, calcitonin gene-related peptide receptor antagonist, using 4 levels...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178435/

データ提供:米国国立医学図書館(NLM)

Atogepant: A Promising Option for Migraine Prophylaxis

The field of [neurology] is continuously searching for effective treatments for [migraine], a debilitating condition that affects millions of people worldwide. This research examines the efficacy of [atogepant], a new oral [calcitonin gene-related peptide receptor antagonist], for the [preventive treatment] of migraine. The authors conducted a [phase 3, double-blind, placebo-controlled randomized clinical trial] to assess the effectiveness of atogepant in reducing the frequency and severity of migraine attacks.

Atogepant Demonstrates Significant Efficacy in Reducing Migraine Days

The study found that atogepant was effective in reducing [mean monthly migraine days (MMDs)] at all doses tested. The study reported a [50% or greater reduction] in MMDs in [over 50%] of patients treated with atogepant compared to [29%] of patients treated with [placebo]. Higher doses of atogepant appeared to produce the greatest responder rates, suggesting that [individualized dosing] could be beneficial for patients.

A Well-Tolerated Option for Migraine Prevention

This study provides encouraging evidence for the use of atogepant as a [safe and effective] treatment for migraine prevention. The well-tolerated nature of atogepant makes it a promising alternative for patients who struggle with the side effects of other migraine preventive medications.

Dr.Camel's Conclusion

Atogepant offers a new ray of hope for migraine sufferers. This well-tolerated and effective treatment provides a significant reduction in migraine days, potentially improving the quality of life for those living with this condition. Further research on atogepant's long-term effects and its potential for personalized dosing could further enhance its benefits for migraine patients.

Date :
  1. Date Completed 2022-06-10
  2. Date Revised 2022-07-17
Further Info :

Pubmed ID

35675076

DOI: Digital Object Identifier

PMC9178435

Related Literature

SNS
PICO Info
in preparation
Languages

English

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