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Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damage in a Laryngopharyngeal Reflux Mouse Model.

Author: ArnoldLeggy A, BluminJoel H, BockJonathan, GoetzChristopher J, JohnstonNikki, MacKinnonAlexander C, MillerJames, OndreyFrank, SamuelsTina L, SeabloomDonna, SilvaggiNicholas R, SmithBrian C, VuksanovicNemanja, WiedmannTimothy S, WuertzBeverly

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to identify small molecule inhibitors of pepsin and test their efficacy to prevent pepsin-mediated laryngeal damage in vivo.
Paper Details　
Original Abstract of the Article :
More than 20% of the US population suffers from laryngopharyngeal reflux. Although dietary/lifestyle modifications and alginates provide benefit to some, there is no gold standard medical therapy. Increasing evidence suggests that pepsin is partly, if not wholly, responsible for damage and inflammat...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35678265

データ提供：米国国立医学図書館（NLM）

Targeting Pepsin to Treat Laryngopharyngeal Reflux

This research delves into the complex world of laryngopharyngeal reflux, a common condition affecting over 20% of the US population. It's like a camel trying to digest a prickly cactus - the digestive system is struggling to keep things in check. The researchers are interested in understanding the role of pepsin, a digestive enzyme, in this condition. They're exploring the potential of small molecules that can specifically target pepsin, offering a new avenue for treatment. It's like finding a special camel that can digest cacti without getting pricked!

Inhibiting Pepsin for Effective Treatment

The study identifies small molecule inhibitors that effectively prevent pepsin-mediated laryngeal damage in mice. These inhibitors offer a promising therapeutic approach for managing laryngopharyngeal reflux. Imagine finding a way to make a camel immune to cactus thorns, a breakthrough in desert survival!

Local Delivery for Targeted Relief

The authors highlight the potential of local, inhaled delivery of these inhibitors. This targeted approach could offer relief from the symptoms of laryngopharyngeal reflux without the systemic side effects of traditional medications. It's like giving the camel a soothing ointment to treat the thorns, rather than making it eat a whole cactus!

Dr.Camel's Conclusion

This research represents a significant step forward in understanding and treating laryngopharyngeal reflux. The discovery of pepsin inhibitors and their potential for local delivery opens up new opportunities for effective and targeted treatment. It's like finding a new oasis in the desert, offering relief and hope to those suffering from this common condition.

Date :
  1. Date Completed 2022-12-16
  2. Date Revised 2023-02-17
Further Info :

Pubmed ID

35678265

DOI: Digital Object Identifier

NIHMS1811733

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Languages

English

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