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No inflammatory effects after acute inhalation of barium sulfate particles in human volunteers.

Author: BrüningThomas, BüngerJürgen, JettkantBirger, KendziaBenjamin, MarekEike-Maximilian, MergetRolf, MonséChristian, RaulfMonika, RosenkranzNina, SchürmeyerLeonie, SeifertChristoph Edzard, WegenerChristopher, WestphalGötz, WiegandFelicitas, van KampenVera

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explored whether the inflammatory effects of particles observed in animal models could be confirmed in humans. Researchers compared the effects of barium sulfate particles (BaSO<sub>4</sub>), considered inert, with zinc oxide (ZnO) which has known inflammatory activity. They found that BaSO<sub>4</sub> did not cause significant inflammatory responses in humans, while ZnO resulted in local and systemic inflammation, confirming the findings from animal studies.
Paper Details　
Original Abstract of the Article :
Label="BACKGROUND" NlmCategory="BACKGROUND">Most threshold limit values are based on animal experiments. Often, the question remains whether these data reflect the situation in humans. As part of a series of investigations in our exposure lab, this study investigates whether the results on the infla...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205122/

データ提供：米国国立医学図書館（NLM）

Barium Sulfate: A Desert Oasis of Inertness

Many substances used in industrial settings can have detrimental effects on human health, much like a desert sandstorm can cause respiratory distress. This study investigates the inflammatory effects of barium sulfate particles, a common industrial material, in human volunteers. The authors conduct a controlled inhalation study, akin to carefully measuring the effects of exposure to different desert environments.

Barium Sulfate: No Sandstorm in Sight

The study found no evidence of inflammatory effects after acute inhalation of barium sulfate particles in human volunteers. This is like finding a desert oasis that is free from dust and pollution, providing a safe haven for the lungs. The authors conclude that barium sulfate particles, at least in acute exposure, do not appear to trigger inflammation in humans, challenging previous assumptions based on animal studies.

A Desert Oasis for Industrial Safety: A Breathable Environment

This research provides reassuring evidence regarding the safety of barium sulfate particles in acute human exposures. This is like discovering a desert oasis that is not only hospitable but also provides a safe environment for human activity. The findings suggest that barium sulfate may be a safer alternative to other industrial materials that can cause respiratory problems, potentially leading to improvements in occupational safety.

Dr.Camel's Conclusion

This study suggests that barium sulfate particles, unlike some other industrial materials, do not appear to trigger inflammation in humans in acute exposure. This is a welcome discovery in the desert of industrial safety, potentially leading to the development of safer working environments.

Date :
  1. Date Completed 2022-06-20
  2. Date Revised 2022-08-23
Further Info :

Pubmed ID

35710385

DOI: Digital Object Identifier

PMC9205122

Related Literature

Article Analysis
・Effects of barium sulfate
SNS
PICO Info
in preparation
Languages

English

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