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Luliconazole Nail Lacquer for the Treatment of Onychomycosis: Formulation, Characterization and In Vitro and Ex Vivo Evaluation.

Author: AgrawalAshish Kumar, DehariDeepa, KumarDeepak, MehataAbhishesh Kumar, ParbatDharmnath, PriyaVishnu, SinghSanjay, SrivastavaAnand Kumar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study develops and evaluates luliconazole nail lacquer (LCZ-NL) as a potential topical treatment for onychomycosis, the most common fungal infection of the nail. The study utilizes a formulation design of experiment (DOE) to optimize LCZ-NL, demonstrating enhanced drug diffusion and antifungal efficacy compared to existing treatments.
Paper Details　
Original Abstract of the Article :
Onychomycosis is the most common fungal infection of the nail affecting the skin under the fingertips and the toes. Currently, available therapy for onychomycosis includes oral and topical therapies, either alone or in combination. Oral antifungal medication has been associated with poor drug bioava...See full text at original site
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引用元：
https://doi.org/10.1208/s12249-022-02324-7

データ提供：米国国立医学図書館（NLM）

Developing a Novel Nail Lacquer for Onychomycosis Treatment

This study focuses on the development and evaluation of a novel luliconazole nail lacquer (LCZ-NL) for the treatment of onychomycosis, a common fungal infection of the nails. Researchers formulated LCZ-NL with penetration enhancers to improve drug delivery and evaluated its efficacy and safety in vitro and ex vivo.

The study utilized a 32 full factorial design of experiment (DOE) to optimize the formulation of LCZ-NL, resulting in a formulation with improved drying time, viscosity, and drug diffusion compared to existing luliconazole nail lacquer products. The optimized formulation demonstrated promising results in terms of antifungal efficacy and transungual permeation.

A Potential Advance in Onychomycosis Treatment

The study highlights the potential of LCZ-NL as a promising topical treatment option for onychomycosis, offering a potential alternative to oral antifungals with their associated side effects. Further clinical trials are needed to evaluate the efficacy and safety of LCZ-NL in human patients.

Onychomycosis: A Persistent Fungal Infection

Onychomycosis is a common and often challenging fungal infection. Effective treatment often requires a long duration of therapy and may involve multiple treatment modalities.

Dr. Camel's Conclusion

The search for effective treatment options for onychomycosis is like a journey through a desert of fungal challenges. This study provides a promising oasis, showcasing a novel luliconazole nail lacquer formulation with potential benefits for patients with this persistent fungal infection. This research highlights the importance of continuous innovation in the field of dermatology to develop safe and effective treatment options for challenging conditions.

Date :
  1. Date Completed 2022-06-28
  2. Date Revised 2022-10-18
Further Info :

Pubmed ID

35750993

DOI: Digital Object Identifier

10.1208/s12249-022-02324-7

SNS
PICO Info
in preparation
Languages

English

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