Inhibition of Axitinib on Buspirone Metabolism in vitro and in vivo.

Author: PangNi-Hong, QuGao-Er, TangCong-Rong, XuRen-Ai, ZhangBo-Wen

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To evaluate the effect of axitinib on buspirone metabolism in vitro and in vivo. METHODS: A microsome incubation assay was performed to study the effect and mechanism of axitinib on buspirone metabolizing. In vivo, buspirone was administered with or without axitinib to Sprague-Dawley rat...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252588/

データ提供:米国国立医学図書館(NLM)

Axitinib's Effect on Buspirone Metabolism

The world of drug interactions is a complex landscape, often resembling a vast desert with unexpected interactions lurking around every corner. This research explores the potential interaction between axitinib, a tyrosine kinase inhibitor, and buspirone, an anti-anxiety medication. The authors investigate the effect of axitinib on the metabolism of buspirone, highlighting the potential for drug interactions that could affect treatment outcomes.

The authors demonstrate that axitinib inhibits the metabolism of buspirone, potentially leading to increased levels of buspirone in the body. This finding highlights the importance of careful monitoring and dose adjustments when these medications are co-administered.

Understanding Drug Interactions

This research underscores the importance of understanding drug interactions and their potential consequences. It highlights the need for close monitoring and communication between patients and their healthcare providers to ensure safe and effective medication use.

The Importance of Communication with Healthcare Providers

If you are taking multiple medications, it is crucial to communicate with your healthcare provider about any potential interactions. They can help to ensure that you are receiving the appropriate care and managing your medications safely.

Dr.Camel's Conclusion

The desert of drug interactions can be a treacherous place to navigate, but this research provides valuable insights into the potential interactions between axitinib and buspirone. It serves as a reminder of the importance of careful medication management and communication with healthcare providers to ensure safe and effective treatment.

Date :
  1. Date Completed 2022-07-08
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

35795848

DOI: Digital Object Identifier

PMC9252588

Related Literature

SNS
PICO Info
in preparation
Languages

English

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