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Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia.

Author: DolmatovaElena, FarokhiErmia, MoazzamiBobak, MoazzamiKasra, MohammadpourZinat, RoohiAria, ZabalaZohyra E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review provides an updated overview of treatment options for critical limb ischemia (CLI), a serious complication of peripheral arterial disease. CLI can lead to limb amputation, and this review explores available treatment strategies for this condition.
Paper Details　
Original Abstract of the Article :
Peripheral arterial disease is a major health problem, and in about 1% to 2% of patients, the disease progresses to critical limb ischaemia (CLI), also known as critical limb-threatening ischaemia. In a substantial number of individuals with CLI, no effective treatment options other than amputation ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266992/

データ提供：米国国立医学図書館（NLM）

Autologous Bone Marrow Mononuclear Cells: A New Oasis in the Desert of Critical Limb Ischemia

Critical limb ischemia (CLI) is a severe form of peripheral artery disease, a condition that can be as debilitating as a treacherous desert journey. For many patients with CLI, amputation may be the only option, a bleak prospect like facing a vast and unforgiving desert. This study explores a promising new treatment approach – local intramuscular transplantation of autologous bone marrow mononuclear cells, a procedure that involves harvesting and injecting the patient's own stem cells into the affected limb.

A New Hope for Limb Salvage

The study highlights the potential of this procedure to improve blood flow and promote healing in patients with CLI, offering a glimmer of hope for limb salvage. It's like discovering a new, hidden oasis in the desert, providing a source of revitalization. The authors acknowledge that further research is needed to fully understand the efficacy and long-term outcomes of this procedure, emphasizing the importance of continuing to explore new avenues for treatment.

Navigating the Path to Regeneration

This study emphasizes the importance of continued research and clinical trials to further evaluate the effectiveness and safety of this treatment approach. It's like meticulously mapping a new route through a complex desert landscape, ensuring a safe and successful journey. The potential of stem cell therapy in CLI is a promising development, offering a new path to healing and regeneration.

Dr.Camel's Conclusion

This study provides a glimmer of hope for those facing the challenges of critical limb ischemia, a condition that can feel as isolating as a vast and unforgiving desert. It's like discovering a new and promising wellspring of healing, offering a path to recovery and limb preservation. The research highlights the immense potential of stem cell therapy in treating CLI, reminding us of the power of human ingenuity and the ongoing quest for better health solutions.

Date :
  1. Date Completed 2022-07-12
  2. Date Revised 2023-07-09
Further Info :

Pubmed ID

35802393

DOI: Digital Object Identifier

PMC9266992

SNS
PICO Info
in preparation
Languages

English

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