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Efficacy and safety of antiseizure medication in post-stroke epilepsy.

Author: GroppaSergiu, KlimpeSven, SandnerKatharina, Stuckrad-BarreSebastian von, UphausTimo, WinterYaroslav

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Overview

This study compared the effectiveness and safety of different antiseizure medications (ASM) in post-stroke epilepsy (PSE). ASMs acting via slow inactivation of sodium channels, like lacosamide and eslicarbazepine, were associated with better seizure control and were well-tolerated. Increased infarction size, cortical involvement, and neurological deficits were associated with increased seizure frequency.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Specific antiseizure medications (ASM) would improve the outcome in post-stroke epilepsy (PSE). The aim of this multicenter observational study was to compare different antiseizure monotherapies in PSE. METHODS: We collected the data from 207 patients with PSE who did not change their i...See full text at original site
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引用元：
https://doi.org/10.1016/j.seizure.2022.07.003

データ提供：米国国立医学図書館（NLM）

New Hope for Post-Stroke Epilepsy

This research explored the efficacy and safety of different antiseizure medications (ASMs) in post-stroke epilepsy (PSE). The study found that ASMs acting via the slow inactivation of sodium channels, such as lacosamide and eslicarbazepine, showed promising results in controlling seizures and were well tolerated.

The Importance of Specific ASM Treatment

The study suggests that the choice of ASM can impact seizure control in PSE. ASMs acting via the slow inactivation of sodium channels appear to be particularly effective in managing seizures in this specific patient population.

Living with Epilepsy

Individuals with epilepsy should consult their doctor for a personalized treatment plan, including the selection of appropriate ASMs. Adhering to medication, managing stress, and making lifestyle changes can significantly improve seizure control and quality of life.

Dr.Camel's Conclusion

This study offers hope for individuals with PSE, suggesting that specific ASMs may provide better seizure control and improve their quality of life. The findings emphasize the need for individualized treatment approaches and ongoing research to further optimize treatment strategies for this challenging condition.
Date :
  1. Date Completed 2022-08-03
  2. Date Revised 2022-08-03
Further Info :

Pubmed ID

35834881

DOI: Digital Object Identifier

10.1016/j.seizure.2022.07.003

Related Literature

Article Analysis
・Side Effects of eslicarbazepine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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