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Novel chlorpromazine derivatives as anti-endometrial carcinoma agents with reduced extrapyramidal side effects.

Author: ChenYang, CuiYunxia, GaoXiaoyan, GongXiaodi, LiJian, LiLijuan, LiuXiaohu, MaoFei, SunXiao, WangJing, WangYudong, WuHuiwen, YangLinlin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the antitumor activity of chlorpromazine (CPZ) derivatives against endometrial carcinoma (EC). The study found that CPZ derivatives 11·2HCl and 18 exhibited greater inhibitory activity than CPZ with less extrapyramidal side effects, suggesting their potential as a safer alternative for the treatment of EC.
Paper Details　
Original Abstract of the Article :
As the traditional conservative remedy for endometrial carcinoma (EC), progesterone has great limitations due to its poor performance, and a new strategy is urgently needed. Our previous work revealed that the antipsychotic drug chlorpromazine (CPZ) has stronger antitumor activity on EC than progest...See full text at original site
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引用元：
https://doi.org/10.1016/j.bioorg.2022.106008

データ提供：米国国立医学図書館（NLM）

Novel Chlorpromazine Derivatives as Anti-Endometrial Carcinoma Agents

This study explores the potential of novel chlorpromazine derivatives as anti-endometrial carcinoma agents. It's like searching for a new oasis in the desert of cancer treatment, seeking more effective and tolerable solutions. The researchers aim to develop new drugs that effectively target endometrial carcinoma while minimizing side effects.

Developing New Therapies for Endometrial Carcinoma

The study demonstrates that certain chlorpromazine derivatives exhibit strong antitumor activity against endometrial carcinoma, potentially offering a new therapeutic approach for this disease. This finding is like discovering a hidden spring in the desert of cancer research – a source of hope for patients seeking new treatments. The researchers highlight the potential of these derivatives to overcome the limitations of traditional therapies.

Improving Cancer Treatment

This research could lead to the development of new and more effective therapies for endometrial carcinoma. It's like finding a more efficient route through the desert, leading to better outcomes for patients. The findings could improve treatment options for women with endometrial carcinoma, potentially leading to better survival rates and quality of life.

Dr.Camel's Conclusion

This study delves into the exciting world of drug development, seeking to uncover new and innovative therapies for endometrial carcinoma. It's like a camel caravan traversing the desert of scientific research, seeking to discover a hidden oasis of knowledge and breakthroughs. This research could lead to new treatments that are not only more effective but also better tolerated by patients.
Date :
  1. Date Completed 2022-08-15
  2. Date Revised 2022-08-16
Further Info :

Pubmed ID

35868106

DOI: Digital Object Identifier

10.1016/j.bioorg.2022.106008

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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