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Paroxetine increases delta opioid responsiveness in sensory neurons.

Author: BrackleyAllison Doyle, JeskeNathaniel A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Paroxetine, an FDA-approved selective serotonin reuptake inhibitor, can enhance peripheral delta opioid receptor (DOR)-mediated analgesic competence in the absence of inflammation by inhibiting G protein-coupled receptor kinase 2 (GRK2). This suggests that paroxetine could be a suitable co-therapy with peripherally-restrictive doses of opioids to improve analgesic efficacy in non-inflammatory pain conditions.
Paper Details　
Original Abstract of the Article :
There are currently no Food and Drug Administration (FDA)-approved delta opioid receptor (DOR)-selective agonists, despite having fewer side effects in rodents and non-human primates compared to traditional mu opioid receptor (MOR) therapeutics (Vanderah, 2010). Targeting peripheral receptors is an ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347309/

データ提供：米国国立医学図書館（NLM）

Paroxetine and Delta Opioid Responsiveness: A Novel Therapeutic Approach

This research explores the potential of paroxetine, a selective serotonin reuptake inhibitor, to enhance the analgesic effects of delta opioid receptors (DOR) in sensory neurons. The study found that paroxetine, by inhibiting GRK2, a protein that regulates DOR activity, can increase DOR responsiveness and improve pain relief.

Potential for Novel Pain Management

The study suggests that paroxetine could be used as a co-therapy with peripherally-restrictive doses of opioids to enhance analgesic efficacy in non-inflammatory pain conditions. This approach has the potential to improve pain relief while reducing the risk of opioid dependence and adverse effects.

Managing Pain Effectively

Individuals experiencing chronic pain should consult their doctor for a personalized treatment plan. Non-pharmacological interventions, such as physical therapy and cognitive-behavioral therapy, can also play a role in managing pain.

Dr.Camel's Conclusion

This study offers a promising new approach to pain management, harnessing the potential of paroxetine to enhance the analgesic effects of delta opioid receptors. The findings have the potential to revolutionize how we treat chronic pain, offering safer and more effective options for patients.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-08-06
Further Info :

Pubmed ID

35882549

DOI: Digital Object Identifier

PMC9347309

Related Literature

Article Analysis
・Side Effects of paroxetine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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