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Saquinavir: From HIV to COVID-19 and Cancer Treatment.

Author: PereiraMariana, ValeNuno

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Saquinavir, the first protease inhibitor for HIV therapy, shows promise for repurposing as a treatment for COVID-19 and cancer. It has demonstrated in silico and in vitro inhibition of the SARS-CoV-2 main protease (3CLpro), as well as anti-cancer effects in various cancers, including cytotoxicity, apoptosis, and improved radiosensitivity.
Paper Details　
Original Abstract of the Article :
Saquinavir was the first protease inhibitor developed for HIV therapy, and it changed the standard of treatment for this disease to a combination of drugs that ultimately led to increased survival of this otherwise deadly condition. Inhibiting the HIV protease impedes the virus from maturing and rep...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313067/

データ提供：米国国立医学図書館（NLM）

Saquinavir: A Versatile Drug with Potential for Repurposing

In the ever-evolving world of [medicine], [drug repurposing] has emerged as a promising strategy to address emerging health challenges. This study explores the potential of [saquinavir], a drug initially developed for [HIV therapy], for repurposing in the treatment of [COVID-19] and [cancer]. The researchers reviewed existing evidence, highlighting the [inhibitory effects] of [saquinavir] on the [SARS-CoV-2 main protease (3CLpro)] and its demonstrated [anticancer activity] in various types of cancer. Their findings suggest that [saquinavir] may hold promise as a [multi-purpose drug], with potential applications in [infectious disease and oncology].

The Adaptability of Saquinavir

This research demonstrates the remarkable adaptability of [saquinavir], highlighting its potential for [repurposing] in various therapeutic settings. The findings suggest that this drug may offer a valuable tool for addressing both [viral infections] and [cancer].

The Promise of Repurposing Drugs

Just as a camel can adapt to diverse environments, so too can [drugs] be repurposed for new applications. This study highlights the potential of [drug repurposing] to accelerate the development of new treatments for [COVID-19] and [cancer], while leveraging existing knowledge and resources.

Dr. Camel's Conclusion

This study explores the potential of saquinavir, a drug originally developed for HIV therapy, for repurposing in the treatment of COVID-19 and cancer. Further research is needed to evaluate its clinical efficacy and safety in these settings.
Date :
  1. Date Completed 2022-07-28
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

35883499

DOI: Digital Object Identifier

PMC9313067

Related Literature

Article Analysis
・Effects of saquinavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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