Paper Details

  1. Home
  2. Paper Details

Comparison of the effects of pindolol and propranolol on exercise performance in patients with angina pectoris.

Author: LisbonaR, MagderS, RipleyR, SamiM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effects of pindolol and propranolol on exercise performance in patients with angina. Both drugs allowed patients to exercise for the same duration, but pindolol had a greater effect on heart rate and oxygen consumption at lower exercise levels.
Paper Details　
Original Abstract of the Article :
The effects of pindolol (mean dose 17 +/- 8 mg/day), a beta-blocking drug with intrinsic sympathomimetic activity (ISA), and propranolol (130 +/- 40 mg/day) on exercise performance in 11 patients with stable angina pectoris were compared. Doses were titrated to symptoms. The design was a randomized,...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0002-9149(87)90906-4

データ提供：米国国立医学図書館（NLM）

Pindolol and Propranolol: A Race Through the Desert of Angina

Angina pectoris, a condition that causes chest pain, is like a mirage in the desert, a deceptive illusion that can lead to discomfort and distress. This study compared the effects of two beta-blocking medications, pindolol and propranolol, on exercise performance in patients with angina. The researchers conducted a randomized, double-blind, crossover study to evaluate the impact of these medications on exercise tolerance.

The study found that both pindolol and propranolol had similar effects on exercise performance, with no significant difference in peak VO2, the maximum amount of oxygen consumed during exercise. While pindolol exhibited intrinsic sympathomimetic activity (ISA), which increased heart rate and cardiac output at lower exercise levels, this did not impact peak exercise performance. It's like two camels racing across the desert, each with their own unique strengths and strategies, but ultimately reaching the finish line together.

Two Camels Racing Through the Desert: A Tale of Angina Treatment

The study highlights that both pindolol and propranolol can effectively manage angina, providing a choice for patients based on their individual needs. It's like having two different paths through the desert, each leading to the same destination.

Finding the Right Path: A Personalized Approach to Angina Treatment

The study emphasizes that the best treatment for angina depends on the individual patient's needs and preferences. It's like choosing the best path through the desert, considering the terrain, the weather, and the caravan's resources.

Dr.Camel's Conclusion

This study offers a comprehensive comparison of pindolol and propranolol, providing valuable insights into the management of angina. It underscores the importance of personalized medicine, tailoring treatment strategies to the unique needs of each patient. Like a skilled camel driver navigating the vast and challenging desert, we must find the right path to ensure a safe and successful journey through the challenges of angina.

Date :
  1. Date Completed 1987-07-21
  2. Date Revised 2019-06-22
Further Info :

Pubmed ID

3591681

DOI: Digital Object Identifier

10.1016/0002-9149(87)90906-4

Related Literature

Article Analysis
・Side Effects of pindolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.