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Effects of inflammation on voriconazole levels: A systematic review.

Author: ChenZebin, ChengJunjie, CuiHao, JiangZhaohui, LaiFangyuan, LiMeng, LiXuejuan, WenFeiqiu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The inflammatory state can significantly affect voriconazole (VRZ) levels, with higher levels of inflammation leading to lower VRZ concentrations. Clinicians dosing VRZ should take into account the patient’s inflammatory state.
Paper Details　
Original Abstract of the Article :
AIMS: This study aimed to review the studies evaluating the effect of the inflammatory state on voriconazole (VRZ) levels. METHODS: The study included randomized clinical trials, cohort studies, and case-control studies that focused on the influence of the inflammatory state on VRZ levels. Followin...See full text at original site
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引用元：
https://doi.org/10.1111/bcp.15495

データ提供：米国国立医学図書館（NLM）

Voriconazole: Navigating the Shifting Sands of Inflammation

Voriconazole (VRZ) is an antifungal medication used to treat a range of infections. This research investigates the impact of inflammation on VRZ levels in the body. The authors conducted a systematic review of studies examining the relationship between inflammation and VRZ levels, exploring the complexities of drug metabolism and the body's response to infection.

Inflammation: A Shifting Landscape

The researchers found that inflammation can significantly influence VRZ levels, leading to variations in drug effectiveness. This is like a camel navigating a desert with shifting sand dunes – the terrain is constantly changing, requiring adjustments to maintain stability and progress. It underscores the importance of individualizing treatment based on the patient's specific condition.

Optimizing Treatment for Individual Needs

This research highlights the need for clinicians to consider the patient's inflammatory state when dosing VRZ. It emphasizes the importance of careful monitoring and potentially adjusting drug dosages to ensure optimal treatment outcomes. It's like a skilled guide, adapting their route through the desert based on the changing conditions, ensuring a safe and successful journey.

Dr. Camel's Conclusion

This research underscores the complexity of drug metabolism and the importance of understanding the interplay between medications and the body's inflammatory response. It encourages continued research to refine our understanding of these interactions and to develop strategies for optimizing VRZ treatment for individual patients. As we journey through the desert of medical knowledge, we must be prepared to adapt to the changing sands and seek new paths to improve patient care.

Date :
  1. Date Completed 2022-11-16
  2. Date Revised 2022-11-27
Further Info :

Pubmed ID

35973037

DOI: Digital Object Identifier

10.1111/bcp.15495

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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