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Systematic review with network meta-analysis on the treatments for latent tuberculosis infection in children and adolescents.

Author: Beraldi-MagalhãesFrancisco, BögerBeatriz, DomingosEric L, FachiMariana M, Fernandez-LlimosFernando, ImazuPriscila, JunkerAllan M, PontaroloRoberto, SantosJosiane M, ToninFernanda S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A systematic review and network meta-analysis of seven trials found that combined therapies of isoniazid plus rifapentine or rifampicin for short-term periods were the most effective treatments for latent tuberculosis infection (LTBI) in children and adolescents. Long-term isoniazid monotherapy at higher doses should be avoided.
Paper Details　
Original Abstract of the Article :
BACKGROUND: We aimed to synthesize the evidence on the efficacy and safety of different treatment regimens for latent tuberculosis infection (LTBI) in children and adolescents. METHODS: A systematic review with network meta-analysis was performed (CRD142933). Searches were conducted in Pubmed and S...See full text at original site
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引用元：
https://doi.org/10.1016/j.jiac.2022.08.023

データ提供：米国国立医学図書館（NLM）

Treating Latent Tuberculosis Infection in Children and Adolescents: A Comprehensive Review

Latent tuberculosis infection (LTBI) is a silent threat, especially in children and adolescents. This systematic review meticulously analyzes the effectiveness and safety of different treatment regimens for LTBI in this vulnerable population. It provides valuable insights for clinicians and policymakers who strive to protect children from the devastating consequences of tuberculosis.

Short-Term Combination Therapies: The Preferred Approach

The review reveals that combined therapies of isoniazid plus rifapentine or rifampicin for shorter periods emerge as the most effective and safest approaches. Long-term isoniazid monotherapy, particularly at higher doses, is associated with increased mortality and should be avoided.

Safeguarding the Health of Future Generations

This research underscores the importance of evidence-based guidelines for LTBI treatment in children and adolescents. Implementing these recommendations can significantly reduce the incidence of active tuberculosis and protect the health of future generations.

Dr. Camel's Conclusion

Just as a camel navigates the vast desert, navigating the complex world of LTBI treatment requires careful consideration of the available evidence. This comprehensive review provides valuable guidance for clinicians to ensure the best possible care for children and adolescents affected by LTBI.

Date :
  1. Date Completed 2022-10-06
  2. Date Revised 2023-01-12
Further Info :

Pubmed ID

36075488

DOI: Digital Object Identifier

10.1016/j.jiac.2022.08.023

Related Literature

Article Analysis
・Effects of rifapentine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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