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Comparative effects of intravenously administered alizapride and prochlorperazine in cisplatin-induced emesis.

Author: DesjardinsR, EllisonR, HymanG, NahasG, RochéH, StooplerM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Alizapride and prochlorperazine, both antiemetics, were compared in patients receiving cisplatin chemotherapy. Alizapride provided complete protection against vomiting in 31%, but prochlorperazine was more effective in reducing the frequency and duration of vomiting.
Paper Details　
Original Abstract of the Article :
A randomized, double blind crossover trial compared the antiemetic effects of alizapride, a benzamide, and prochlorperazine, a phenothiazine, both administered intravenously to 32 patients treated with chemotherapy combinations containing cisplatin. The total dose of alizapride administered to each ...See full text at original site
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引用元：
https://doi.org/10.3109/07357908709018461

データ提供：米国国立医学図書館（NLM）

Combating Cisplatin-Induced Emesis: Alizapride vs. Prochlorperazine

Cisplatin is a powerful chemotherapy drug used to treat various cancers. However, it is notorious for causing severe nausea and vomiting. This research compares the antiemetic efficacy of alizapride and prochlorperazine, two medications used to prevent cisplatin-induced emesis. The study found that both drugs were effective in reducing nausea and vomiting, but prochlorperazine was more effective in preventing severe emesis. The authors recommend further investigation of optimal dosage and pharmacokinetic properties of these antiemetic drugs.

Finding the Right Balance: Managing Cisplatin-Induced Emesis

This study underscores the importance of effective antiemetic strategies for patients receiving cisplatin chemotherapy. While both alizapride and prochlorperazine showed antiemetic effects, the study highlights the potential benefit of prochlorperazine in preventing severe emesis. This information can guide clinicians in selecting the most appropriate antiemetic regimen for individual patients.

Improving Patient Well-Being: Minimizing Chemotherapy Side Effects

The goal of cancer treatment is not only to eradicate cancer cells but also to improve the overall quality of life for patients. Emesis is a common and distressing side effect of chemotherapy, which can significantly impact patients' well-being. By optimizing antiemetic strategies, we can minimize the discomfort and improve the quality of life for patients undergoing cancer treatment.

Dr.Camel's Conclusion

Just as a camel can navigate the harsh desert landscape with its ability to withstand dehydration, patients undergoing cisplatin chemotherapy often face the challenge of nausea and vomiting. This study sheds light on the potential of antiemetic drugs in mitigating these side effects, reminding us that a multi-faceted approach is key to ensuring patient comfort and well-being during cancer treatment.

Date :
  1. Date Completed 1987-09-14
  2. Date Revised 2019-09-12
Further Info :

Pubmed ID

3607576

DOI: Digital Object Identifier

10.3109/07357908709018461

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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